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Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer

Cited 37 time in Web of Science Cited 41 time in Scopus
Authors
No, Jae Hong; Jeon, Yong-Tark; Park, In-Ae; Kim, Yong-Beom; Kim, Jae Weon; Park, Noh-Hyun; Kang, Soon-Beom; Han, Jae Yong; Lim, Jeong Mook; Song, Yong-Sang
Issue Date
2011
Publisher
Elsevier
Citation
Gynecologic Oncology, vol.121 no.1, pp. 8-12
Keywords
p-mTORp-4EBP1p-p70S6KEpithelial ovarian cancer
Abstract
Objective. Activation of the mammalian target of rapamycin (mTOR) pathway enhances cell survival and growth by regulating the efficiency of protein translation. This study was conducted to evaluate the association of activated mTOR signaling molecules with the clinicopathologic characteristics in epithelial ovarian cancer.
Methods. Immunohistochemical staining with antibodies against p-4EBP1, p-mTOR, and p-p70S6K were performed on specimens of 103 patients with ovarian cancer. Tumors were classified as chemoresistant in cases where time to recurrence after the end of chemotherapy was shorter than 6 months.
Results. Expressions of p-mTOR, p-4EBP1, and p-p70S6K were detected in 47.6%, 85.4%, and 64.1% of all patients, respectively. p-4EBP1 overexpression was associated with advanced stage (p=0.04), histologic grade (pb0.01), residual mass (pb0.01), shorter disease-free survival rate (p=0.01) and chemoresistance (p=0.02). p-p70S6K was associated with residual mass with marginal significance (p=0.06). p-4EBP1 expression was correlated with p-p70S6K expression (r=0.42, pb0.01), whereas p-mTOR was not associated with expression of its downstream effectors or prognostic factors.
Conclusions. Our findings suggest that p-4EBP1 expression was associated with poor prognostic factors of ovarian cancer and that p-4EBP1 overexpression may be a prognostic biomarker of ovarian cancer.
ISSN
0090-8258
Language
English
URI
http://hdl.handle.net/10371/100301
DOI
https://doi.org/10.1016/j.ygyno.2010.12.364
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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