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Germline modification and engineering in avian species

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Authors
Lee, Hong Jo; Lee, Hyung Chul; Han, Jae Yong
Issue Date
2015
Publisher
Springer
Citation
Molecules and Cells, vol.38 no.9, pp. 743-749
Keywords
aviangermline competent cellgermline modificationgenome editing
Description
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To
view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
Abstract
Production of genome-edited animals using germline-competent cells and genetic modification tools has provided opportunities for investigation of biological mechanisms in various organisms. The recently reported programmed genome editing technology that can induce gene modification at a target locus in an efficient and precise manner facilitates establishment of animal models. In this regard, the demand for genome-edited avian species, which are some of the most suitable model animals due to their unique embryonic development, has also increased. Furthermore, germline chimera production through long-term culture of chicken primordial germ cells (PGCs) has facilitated research on production of genome-edited chickens. Thus, use of avian germline modification is promising for development of novel avian models for research of disease control and various biological mechanisms. Here, we discuss recent progress in genome modification technology in avian species and its applications and future strategies.
ISSN
1016-8478
Language
English
URI
http://hdl.handle.net/10371/100427
DOI
https://doi.org/10.14348/molcells.2015.0225
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Food and Animal Biotechnology (식품·동물생명공학부)Journal Papers (저널논문_식품·동물생명공학부)
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