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Prognostic significance of loss of c-fos protein in gastric carcinoma
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- Authors
- Issue Date
- 2007-12-26
- Publisher
- Elsevier
- Citation
- Pathol Oncol Res 13(4):284-289, 2007
- Keywords
- Carcinoma/metabolism/mortality/*pathology ; Disease Progression ; Prognosis ; Proto-Oncogene Proteins c-fos/*metabolism ; Survival Rate ; Stomach Neoplasms/metabolism/mortality/*pathology
- Abstract
- c-fos was first identified as a viral oncoprotein, and has been studied in terms of its oncogenic function in tumorigenesis. Many experimental and clinical data indicated that c-fos expression plays a role in the progression of several types of carcinomas. However, some recent studies challenge this view as they indicate that c-fos has tumor suppressor activity. In the present study, we assessed c-fos protein expression in 625 consecutive gastric cancers immunohistochemically, and analyzed its relationship with clinicopathologic factors and survival. We found that a loss of c-fos expression is correlated with a more advanced stage, lymph node metastasis, lymphatic invasion and shorter survival, indicating that c-fos expression in gastric cancer cells is lost during progression and that this loss is associated with a poor prognosis. The above findings suggest that loss of c-fos expression has tumor suppressor activity in gastric cancer and we suspect that this suppressor activity might be related to the pro-apoptotic function of c-fos.
- ISSN
- 1219-4956 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18158562
https://hdl.handle.net/10371/10043
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