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A genome-wide scan for signatures of directional selection in domesticated pigs
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Sunjin | - |
dc.contributor.author | Kim, Tae-Hun | - |
dc.contributor.author | Lee, Kyung-Tai | - |
dc.contributor.author | Kwak, Woori | - |
dc.contributor.author | Lee, Taeheon | - |
dc.contributor.author | Lee, Si-Woo | - |
dc.contributor.author | Kim, Myung-Jick | - |
dc.contributor.author | Cho, Kyuho | - |
dc.contributor.author | Kim, Namshin | - |
dc.contributor.author | Chung, Won-Hyong | - |
dc.contributor.author | Sung, Samsun | - |
dc.contributor.author | Park, Taesung | - |
dc.contributor.author | Cho, Seoae | - |
dc.contributor.author | Groenen, Martien AM | - |
dc.contributor.author | Nielsen, Rasmus | - |
dc.contributor.author | Kim, Yuseob | - |
dc.contributor.author | Kim, Heebal | - |
dc.date.accessioned | 2017-02-07T01:42:57Z | - |
dc.date.available | 2017-02-07T01:42:57Z | - |
dc.date.issued | 2015-02-25 | - |
dc.identifier.citation | BMC Genomics, 16(1):130 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/100472 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. | ko_KR |
dc.description.abstract | Background
Animal domestication involved drastic phenotypic changes driven by strong artificial selection and also resulted in new populations of breeds, established by humans. This study aims to identify genes that show evidence of recent artificial selection during pig domestication. Results Whole-genome resequencing of 30 individual pigs from domesticated breeds, Landrace and Yorkshire, and 10 Asian wild boars at ~16-fold coverage was performed resulting in over 4.3 million SNPs for 19,990 genes. We constructed a comprehensive genome map of directional selection by detecting selective sweeps using an F ST-based approach that detects directional selection in lineages leading to the domesticated breeds and using a haplotype-based test that detects ongoing selective sweeps within the breeds. We show that candidate genes under selection are significantly enriched for loci implicated in quantitative traits important to pig reproduction and production. The candidate gene with the strongest signals of directional selection belongs to group III of the metabolomics glutamate receptors, known to affect brain functions associated with eating behavior, suggesting that loci under strong selection include loci involved in behaviorial traits in domesticated pigs including tameness. Conclusions We show that a significant proportion of selection signatures coincide with loci that were previously inferred to affect phenotypic variation in pigs. We further identify functional enrichment related to behavior, such as signal transduction and neuronal activities, for those targets of selection during domestication in pigs. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Pig | ko_KR |
dc.subject | Domestication | ko_KR |
dc.subject | Selective sweep | ko_KR |
dc.subject | Directional selection | ko_KR |
dc.subject | Quantitative traits | ko_KR |
dc.title | A genome-wide scan for signatures of directional selection in domesticated pigs | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 문선진 | - |
dc.contributor.AlternativeAuthor | 김태훈 | - |
dc.contributor.AlternativeAuthor | 이경태 | - |
dc.contributor.AlternativeAuthor | 곽우리 | - |
dc.contributor.AlternativeAuthor | 이태헌 | - |
dc.contributor.AlternativeAuthor | 이시우 | - |
dc.contributor.AlternativeAuthor | 김명직 | - |
dc.contributor.AlternativeAuthor | 조규호 | - |
dc.contributor.AlternativeAuthor | 김남신 | - |
dc.contributor.AlternativeAuthor | 정원형 | - |
dc.contributor.AlternativeAuthor | 성삼선 | - |
dc.contributor.AlternativeAuthor | 박태성 | - |
dc.contributor.AlternativeAuthor | 조서애 | - |
dc.contributor.AlternativeAuthor | 김유섭 | - |
dc.contributor.AlternativeAuthor | 김희발 | - |
dc.identifier.doi | 10.1186/s12864-015-1330-x | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | Moon et al.; licensee BioMed Central. | - |
dc.date.updated | 2017-01-06T10:05:37Z | - |
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