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Comparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma

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dc.contributor.authorKang, Sokbom-
dc.contributor.authorKim, Jae Weon-
dc.contributor.authorKang, Gyeong Hoon-
dc.contributor.authorLee, Sun-
dc.contributor.authorPark, Noh Hyun-
dc.contributor.authorSong, Yong Sang-
dc.contributor.authorPark, Sang Yoon-
dc.contributor.authorKang, Soon Beom-
dc.contributor.authorLee, Hyo Pyo-
dc.date.accessioned2009-10-05-
dc.date.available2009-10-05-
dc.date.issued2005-12-05-
dc.identifier.citationInt J Cancer 2006;118(9):2168-71.en
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10371/10047-
dc.description.abstractThe incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for the molecular diagnosis of CA and endometrial adenocarcinoma (EA). Using the bisulfite-modification technique and methylation-specific PCR, we examined the aberrant promoter hypermethylation patterns of 9 tumor suppressor genes (APC, DAPK, CDH1, HLTF, hMLH1, p16, RASSF1A, THBS1 and TIMP3) in 62 CSCCs, 30 CAs and 21 EAs. After Bonferroni correction adjustment (statistically significant at p < 0.0055), we found that the aberrant hypermethylations of CDH1 and DAPK were more frequent in CSCCs than in CAs (80.6% vs. 43.3%, p = 0.001; 77.4% vs. 46.7%, p = 0.005), whereas HLTF and TIMP3 were more frequently methylated in CAs (3.2% vs. 43.3%, p < 0.001; 8.1% vs. 53.3%, p = 0.001). The hypermethylations of RASSF1A and APC were more frequent in CAs than in CSCCs, but this was not significant (9.7% vs. 33.3%, p = 0.008; and 14.5% vs. 40.0%, respectively, p = 0.009). In addition, RASSF1A hypermethylation was significantly more frequent in EAs than in CAs (81.0% vs. 33.3%, p = 0.001). In conclusion, the existence of these unique methylation patterns in these cancers suggests that their tumorigenesis may involve different epigenetic mechanisms.en
dc.language.isoenen
dc.publisherWiley-Blackwellen
dc.subjectAdenocarcinoma/*genetics/pathologyen
dc.subjectCarcinoma, Squamous Cell/*genetics/pathologyen
dc.subject*DNA Methylationen
dc.subject*DNA, Neoplasmen
dc.subjectEndometrial Neoplasms/*genetics/pathologyen
dc.subjectEpigenesis, Geneticen
dc.subjectFemaleen
dc.subjectGenes, Neoplasmen
dc.subjectHumansen
dc.subjectPolymerase Chain Reactionen
dc.subjectPromoter Regions, Geneticen
dc.subjectUterine Cervical Neoplasms/*genetics/pathologyen
dc.titleComparison of DNA hypermethylation patterns in different types of uterine cancer: cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor강석범-
dc.contributor.AlternativeAuthor김재원-
dc.contributor.AlternativeAuthor강경훈-
dc.contributor.AlternativeAuthor이선-
dc.contributor.AlternativeAuthor박노현-
dc.contributor.AlternativeAuthor송용상-
dc.contributor.AlternativeAuthor박상윤-
dc.contributor.AlternativeAuthor강순범-
dc.contributor.AlternativeAuthor이효표-
dc.identifier.doi10.1002/ijc.21609-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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