Alcohol consumption, body mass index and breast cancer risk by hormone receptor status: Women Lifestyle and Health Study

Description: This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.

Abstract: Abstract

Background
We aimed to estimate the effect of alcohol consumption on breast cancer risk and to test whether overweight and obesity modifies this association.

Methods
We included in the analysis 45,233 women enrolled in the Swedish Womens Lifestyle and Health study between 1991 and 1992. Participants were followed for occurrence of breast cancer and death until December 2009. Poisson regression models were used, and analyses were done for overall breast cancer and for estrogen receptor positive or negative (ER+, ER-) and progesterone receptor positive and negative (PR+, PR-) tumors separately.

Results
A total of 1,385 breast cancer cases were ascertained during the follow-up period. Overall, we found no statistically significant association between alcohol intake and breast cancer risk after adjustment for confounding, with an estimated relative risk (RR) of 1.01 (95% CI: 0.98–1.04) for an increment in alcohol consumption of 5g/day. A statistically significant elevated breast cancer risk associated with higher alcohol consumption was found only among women with BMI ≤25 (RR 1.03, 95% CI 1.0–1.05 per 5g/day increase).

Conclusion
An increase in breast cancer risk with higher alcohol consumption was found for breast cancers in women with a BMI ≤25kg/m2.

Files in This Item:

Appears in Collections:

Show Full Item Record

Find it @ SNU

SNS Share