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Population attributable risks of modifiable reproductive factors for breast and ovarian cancers in Korea

Cited 9 time in Web of Science Cited 11 time in Scopus
Authors
Park, Boyoung; Park, Sohee; Shin, Hai-Rim; Shin, Aesun; Yeo, Yohwan; Choi, Ji-Yeob; Jung, Kyu-Won; Kim, Byoung-Gie; Kim, Yong-Man; Noh, Dong-Young; Ahn, Sei-Hyun; Kim, Jae Weon; Kang, Sokbom; Kim, Jae Hoon; Kim, Tae Jin; Kang, Daehee; Yoo, Keun-Young; Park, Sue K.
Issue Date
2016-01-06
Publisher
BioMed Central
Citation
BMC Cancer, 16(1):5
Keywords
Population attributable fractionBreast cancerOvarian cancerModifiable factorsReproductive factors
Description
This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made.
Abstract
Abstract

Background
Breast and ovarian cancers are predominant female cancers with increasing prevalence. The purpose of this study was to estimate the population attributable risks (PARs) of breast and ovarian cancer occurrence based on the relative risks (RRs) of modifiable reproductive factors and population-specific exposure prevalence.


Methods
The PAR was calculated by using the 1990 standardized prevalence rates, the 2010 national cancer incidence with a 20 year lag period, the meta-analyzed RRs from studies conducted in the Korean population for breast cancer, and the meta-analyzed RRs from a Korean epithelial ovarian cancer study and a prior meta-analysis, and ovarian cancer cohort results up to 2012. For oral contraceptive and hormone replacement therapy use, we did not consider lag period.


Results
The summary PARs for modifiable reproductive factors were 16.7 % (95 % CI 15.8–17.6) for breast cancer (2404 cases) and 81.9 % (95 % CI 55.0–100.0) for ovarian cancer (1579 cases). The modifiable reproductive factors included pregnancy/age at first birth (8.0 %), total period of breastfeeding (3.1 %), oral contraceptive use (5.3 %), and hormone replacement therapy use (0.3 %) for breast cancer and included breastfeeding experience (2.9 %), pregnancy (1.2 %), tubal ligation (24.5 %), and oral contraceptive use (53.3 %) for ovarian cancer.


Conclusions
Despite inherent uncertainties in the risk factors for breast and ovarian cancers, we suggest that appropriate long-term control of modifiable reproductive factors could reduce breast and ovarian cancer incidences and their related burdens by 16.7 % and 81.9 %, respectively.
Language
English
URI
http://hdl.handle.net/10371/100529
DOI
https://doi.org/10.1186/s12885-015-2040-0
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College of Medicine/School of Medicine (의과대학/대학원)Preventive Medicine (예방의학전공)Journal Papers (저널논문_예방의학전공)
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