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Power spectral aspects of the default mode network in schizophrenia: an MEG study

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Authors
Kim, June Sic; Shin, Kyung Soon; Jung, Wi Hoon; Kim, Sung Nyun; Kwon, Jun Soo; Chung, Chun Kee
Issue Date
2014-09-05
Publisher
BioMed Central
Citation
BMC Neuroscience, 15(1):104
Keywords
Default mode networkMagnetoencephalographyPower spectral densityAlphaSchizophrenia
Description
This is an Open Access article distributed under the terms of the Creative
Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly credited.
Abstract
Abstract

Background
Symptoms of schizophrenia are related to deficits in self-monitoring function, which may be a consequence of irregularity in aspects of the default mode network (DMN). Schizophrenia can also be characterized by a functional abnormality of the brain activity that is reflected in the resting state. Oscillatory analysis provides an important understanding of resting brain activity. However, conventional methods using electroencephalography are restricted because of low spatial resolution, despite their excellent temporal resolution.
The aim of this study was to investigate resting brain oscillation and the default mode network based on a source space in various frequency bands such as theta, alpha, beta, and gamma using magnetoencephalography. In addition, we investigated whether these resting and DMN activities could distinguish schizophrenia patients from normal controls. To do this, the power spectral density of each frequency band at rest was imaged and compared on a spatially normalized brain template in 20 patients and 20 controls.


Results
The spatial distribution of DMN activity in the alpha band was similar to that found in previous fMRI studies. The posterior cingulate cortex (PCC) and lateral inferior parietal cortex were activated at rest, while the medial prefrontal cortex (MPFC) was deactivated at rest rather than during the task. Although the MPFC and PCC regions exhibited contrasting activation patterns, these two regions were significantly coherent at rest. The DMN and resting activities of the PCC were increased in schizophrenia patients, predominantly in the theta and alpha bands.


Conclusions
By using MEG to identify the DMN regions, predominantly in the alpha band, we found that both resting and DMN activities were augmented in the posterior cingulate in schizophrenia patients. Furthermore, schizophrenia patients exhibited decreased coherence between the PCC and MPFC in the gamma band at rest.
Language
English
URI
http://hdl.handle.net/10371/100653
DOI
https://doi.org/10.1186/1471-2202-15-104
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College of Medicine/School of Medicine (의과대학/대학원)Neurosurgery (신경외과학전공)Journal Papers (저널논문_신경외과학전공)
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