Browse

Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma

DC Field Value Language
dc.contributor.authorMoon, Kyung Chul-
dc.contributor.authorCho, Soo Youn-
dc.contributor.authorLee, Hye Seung-
dc.contributor.authorJeon, Yoon Kyung-
dc.contributor.authorChung, Jin-Haeng-
dc.contributor.authorJung, Kyeong Cheon-
dc.contributor.authorChung, Doo Hyun-
dc.date.accessioned2009-10-05T09:11:38Z-
dc.date.available2009-10-05T09:11:38Z-
dc.date.issued2006-
dc.identifier.citationArch Pathol Lab Med. 2006;130:1320-1325en
dc.identifier.issn0003-9985-
dc.identifier.urihttp://hdl.handle.net/10371/10143-
dc.description.abstractCONTEXT: E-Cadherin and beta-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and beta-catenin expressions of this tumor have not been documented, to our knowledge. OBJECTIVE: To characterize the E-cadherin and beta-catenin expressions in SRCC of the lung. DESIGN: An immunohistochemical evaluation of E-cadherin and beta-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. RESULTS: Membranous E-cadherin and beta-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear beta-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear beta-catenin accumulation (0/10). CONCLUSIONS: Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or beta-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and beta-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs.en
dc.description.sponsorshipThis study was supported by grant 21-2005-024 from the Seoul
National University Hospital.
en
dc.language.isoenen
dc.publisherCollege of American Pathologistsen
dc.titleDistinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinomaen
dc.typeArticleen
dc.contributor.AlternativeAuthor문경철-
dc.contributor.AlternativeAuthor조수연-
dc.contributor.AlternativeAuthor이혜승-
dc.contributor.AlternativeAuthor전윤경-
dc.contributor.AlternativeAuthor정지행-
dc.contributor.AlternativeAuthor정경천-
dc.contributor.AlternativeAuthor정두현-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse