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Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moon, Kyung Chul | - |
dc.contributor.author | Cho, Soo Youn | - |
dc.contributor.author | Lee, Hye Seung | - |
dc.contributor.author | Jeon, Yoon Kyung | - |
dc.contributor.author | Chung, Jin-Haeng | - |
dc.contributor.author | Jung, Kyeong Cheon | - |
dc.contributor.author | Chung, Doo Hyun | - |
dc.date.accessioned | 2009-10-05T09:11:38Z | - |
dc.date.available | 2009-10-05T09:11:38Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Arch Pathol Lab Med. 2006;130:1320-1325 | en |
dc.identifier.issn | 0003-9985 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10143 | - |
dc.description.abstract | CONTEXT: E-Cadherin and beta-catenin complexes have been suggested to have critical roles in cancer development and progression. Primary signet ring cell carcinoma (SRCC) of the lung is a rare variant of pulmonary adenocarcinoma, and E-cadherin and beta-catenin expressions of this tumor have not been documented, to our knowledge. OBJECTIVE: To characterize the E-cadherin and beta-catenin expressions in SRCC of the lung. DESIGN: An immunohistochemical evaluation of E-cadherin and beta-catenin expressions in 10 cases of SRCC of the lung, 10 cases of conventional pulmonary adenocarcinoma, 10 cases of gastric SRCC, and 10 cases of colorectal SRCC was performed. RESULTS: Membranous E-cadherin and beta-catenin expressions were frequently reduced or absent in all types of tumors tested. Aberrant E-cadherin localization and nuclear beta-catenin accumulation were frequently found in gastric (6/10 and 5/10, respectively) and colorectal (7/10 and 9/ 10, respectively) SRCCs, whereas SRCC of the lung rarely showed aberrant E-cadherin localization (1/10) or nuclear beta-catenin accumulation (0/10). CONCLUSIONS: Signet ring cell carcinoma of the lung rarely showed aberrant E-cadherin localization or beta-catenin nuclear accumulation, which are frequent events in gastric and colorectal SRCCs. These results suggest that the biologic roles of E-cadherin and beta-catenin complexes in SRCC of the lung differ from their roles in gastric or colorectal SRCCs. | en |
dc.description.sponsorship | This study was supported by grant 21-2005-024 from the Seoul
National University Hospital. | en |
dc.language.iso | en | en |
dc.publisher | College of American Pathologists | en |
dc.title | Distinct expression patterns of E-cadherin and beta-catenin in signet ring cell carcinoma components of primary pulmonary adenocarcinoma | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 문경철 | - |
dc.contributor.AlternativeAuthor | 조수연 | - |
dc.contributor.AlternativeAuthor | 이혜승 | - |
dc.contributor.AlternativeAuthor | 전윤경 | - |
dc.contributor.AlternativeAuthor | 정지행 | - |
dc.contributor.AlternativeAuthor | 정경천 | - |
dc.contributor.AlternativeAuthor | 정두현 | - |
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