Publications
Detailed Information
Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma
Cited 36 time in
Web of Science
Cited 38 time in Scopus
- Authors
- Issue Date
- 2005-05-10
- Publisher
- Springer Verlag
- Citation
- Cancer Chemother Pharmacol 56:271.
- Keywords
- Anaplastic large cell lymphoma ; Genistein ; Apoptosis ; Akt ; Caspase
- Abstract
- More than half of anaplastic large-cell lymphoma
(ALCL) are associated with chromosomal
translocation t(2;5)(p23;q35) that leads to the expression
of nucleophosmin-anaplastic lymphoma kinase (NPMALK)
oncoprotein. NPM-ALK activates the antiapoptotic
phosphatidylinositol-3 kinase/Akt (PI3K/Akt) signaling
pathway, which plays a critical role in cell
survival and apoptosis. Inhibition of the PI3K/Akt
pathway has been considered as a therapeutic target for
cancer where PI3K/Akt activation is a causative factor.
Genistein, a natural isoflavonoid found in soy products,
has been shown to inhibit cell growth and induce
apoptosis in a wide variety of cell lines. Here, we demonstrated
that treatment of two t(2;5) ALCL cell lines,
SUDHL-1 and Karpas299, with genistein induced
apoptosis in a time- and dose-dependent manner. Concurrently,
these cells exhibited a decrease in Akt protein
levels and subsequent downregulation of Akt activity
(Akt phosphorylation). Furthermore, genistein treatment
induced mitochondrial membrane potential
change, caspase-3 activation and PARP cleavage. From
these results, we conclude that inhibition of the Akt
signaling pathway and induction of apoptosis by genistein
could be used as a new treatment modality for the
prevention and/or treatment of t(2;5) ALCL and other
hematopoietic malignancies.
- ISSN
- 0344-5704 (print)
1432-0843 (online)
- Language
- English
- Files in This Item:
- There are no files associated with this item.
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.