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FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model
DC Field | Value | Language |
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dc.contributor.author | Park, Hee Sun | - |
dc.contributor.author | Chung, Jin Wook | - |
dc.contributor.author | Jae, Hwan Jun | - |
dc.contributor.author | Kim, Young Il | - |
dc.contributor.author | Son, Kyu Ri | - |
dc.contributor.author | Lee, Min Jong | - |
dc.contributor.author | Park, Jae Hyung | - |
dc.contributor.author | Kang, Won Jun | - |
dc.contributor.author | Yoon, Jung Hwan | - |
dc.contributor.author | Chung, Hesson | - |
dc.contributor.author | Lee, Kichang | - |
dc.date.accessioned | 2009-10-08T22:54:23Z | - |
dc.date.available | 2009-10-08T22:54:23Z | - |
dc.date.issued | 2007-06-08 | - |
dc.identifier.citation | Korean J Radiol 2007;8(3):216-224 | en |
dc.identifier.issn | 1229-6929 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17554189 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10350 | - |
dc.description.abstract | OBJECTIVE: We wanted to investigate the feasibility of using FDG-PET for evaluating the antitumor effect of intraarterial administration of a hexokinase II inhibitor, 3-bromopyruvate (3-BrPA), in a rabbit VX2 liver tumor model. MATERIALS AND METHODS: VX2 carcinoma was grown in the livers of ten rabbits. Two weeks later, liver CT was performed to confirm appropriate tumor growth for the experiment. After tumor volume-matched grouping of the rabbits, transcatheter intraarterial administration of 3-BrPA was performed (1 mM and 5 mM in five animals each, respectively). FDG-PET scan was performed the day before, immediately after and a week after 3-BrPA administration. FDG uptake was semiquantified by measuring the standardized uptake value (SUV). A week after treatment, the experimental animals were sacrificed and the necrosis rates of the tumors were calculated based on the histopathology. RESULTS: The SUV of the VX2 tumors before treatment (3.87+/-1.51 [mean+/-SD]) was significantly higher than that of nontumorous liver parenchyma (1.72+/-0.34) (p < 0.0001, Mann-Whitney U test). The SUV was significantly decreased immediately after 3-BrPA administration (2.05+/-1.21) (p = 0.002, Wilcoxon signed rank test). On the one-week follow up PET scan, the FDG uptake remained significantly lower (SUV 1.41+/-0.73) than that before treatment (p = 0.002), although three out of ten animals showed a slightly increasing tendency for the FDG uptake. The tumor necrosis rate ranged from 50.00% to 99.90% (85.48%+/-15.87). There was no significant correlation between the SUV or the SUV decrease rate and the tumor necrosis rate in that range. CONCLUSION: Even though FDG-PET cannot exactly reflect the tumor necrosis rate, FDG-PET is a useful modality for the early assessment of the antitumor effect of intraarterial administration of 3-BrPA in VX2 liver tumor. | en |
dc.language.iso | en | - |
dc.publisher | The Korean Radiological Society | en |
dc.subject | Animals | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Enzyme Inhibitors/*pharmacology | en |
dc.subject | Feasibility Studies | en |
dc.subject | Fluorodeoxyglucose F18 | en |
dc.subject | Infusions, Intra-Arterial | en |
dc.subject | Injections, Intra-Arterial | en |
dc.subject | Liver Neoplasms, Experimental/*drug therapy/pathology/*radionuclide | en |
dc.subject | imaging | en |
dc.subject | Necrosis | en |
dc.subject | Pyruvate Dehydrogenase Complex/antagonists & inhibitors | en |
dc.subject | Pyruvates/*pharmacology | en |
dc.subject | Rabbits | en |
dc.subject | Radiopharmaceuticals | en |
dc.subject | Positron-Emission Tomography | - |
dc.title | FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 박희선 | - |
dc.contributor.AlternativeAuthor | 정진욱 | - |
dc.contributor.AlternativeAuthor | 제환준 | - |
dc.contributor.AlternativeAuthor | 손규리 | - |
dc.contributor.AlternativeAuthor | 이민종 | - |
dc.contributor.AlternativeAuthor | 박재형 | - |
dc.contributor.AlternativeAuthor | 강원준 | - |
dc.contributor.AlternativeAuthor | 윤정환 | - |
dc.contributor.AlternativeAuthor | 정혜선 | - |
dc.contributor.AlternativeAuthor | 이기창 | - |
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