Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas

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Jung, In Mok; Chung, Jung Kee; Kim, Young A; Kim, Je Eun; Heo, Seung Chul; Ahn, Young Joon; Hwang, Ki-Tae; Kim, Byeong Gwan; Lee, Kook Lae; Kim, Chul Woo; Kim, Woo Ho; Chang, Mee Soo
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대한의학회 = Korean Academy of Medical Science
J Korean Med Sci 2007; 22: 855-61
Stomach NeoplasmsHerpesvirus 4, HumanBeta CateninCadherinsPrognosis
Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relationship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, beta-catenin, and E-cadherin immunohistochemistry, and clinicopathological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplasmic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with beta-catenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient's survival (p<0.05). In conclusion, beta-catenin activation through nuclear accumulation hardly occurred in EBV-infected gastric carcinomas. The combined immunoexpression pattern of beta-catenin and E-cadherin can be used as a prognostic marker in gastric carcinomas.
1011-8934 (Print)
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