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Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas

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dc.contributor.authorJung, In Mok-
dc.contributor.authorChung, Jung Kee-
dc.contributor.authorKim, Young A-
dc.contributor.authorKim, Je Eun-
dc.contributor.authorHeo, Seung Chul-
dc.contributor.authorAhn, Young Joon-
dc.contributor.authorHwang, Ki-Tae-
dc.contributor.authorKim, Byeong Gwan-
dc.contributor.authorLee, Kook Lae-
dc.contributor.authorKim, Chul Woo-
dc.contributor.authorKim, Woo Ho-
dc.contributor.authorChang, Mee Soo-
dc.date.accessioned2009-10-29T04:40:35Z-
dc.date.available2009-10-29T04:40:35Z-
dc.date.issued2007-
dc.identifier.citationJ Korean Med Sci 2007; 22: 855-61en
dc.identifier.issn1011-8934 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17982235-
dc.identifier.urihttps://hdl.handle.net/10371/10895-
dc.description.abstractActivated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relationship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, beta-catenin, and E-cadherin immunohistochemistry, and clinicopathological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplasmic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with beta-catenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient's survival (p<0.05). In conclusion, beta-catenin activation through nuclear accumulation hardly occurred in EBV-infected gastric carcinomas. The combined immunoexpression pattern of beta-catenin and E-cadherin can be used as a prognostic marker in gastric carcinomas.en
dc.description.sponsorship*This study was supported by a research grant funded
by the Seoul National University College of Medicine
(2005).
en
dc.language.isoen-
dc.publisher대한의학회 = Korean Academy of Medical Scienceen
dc.subjectStomach Neoplasmsen
dc.subjectHerpesvirus 4, Humanen
dc.subjectBeta Cateninen
dc.subjectCadherinsen
dc.subjectPrognosisen
dc.titleEpstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomasen
dc.typeArticleen
dc.contributor.AlternativeAuthor정인목-
dc.contributor.AlternativeAuthor정중기-
dc.contributor.AlternativeAuthor김영아-
dc.contributor.AlternativeAuthor김제은-
dc.contributor.AlternativeAuthor허승철-
dc.contributor.AlternativeAuthor안영준-
dc.contributor.AlternativeAuthor황기태-
dc.contributor.AlternativeAuthor김병관-
dc.contributor.AlternativeAuthor이국래-
dc.contributor.AlternativeAuthor김철우-
dc.contributor.AlternativeAuthor김우호-
dc.contributor.AlternativeAuthor장미수-
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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