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Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, In Mok | - |
dc.contributor.author | Chung, Jung Kee | - |
dc.contributor.author | Kim, Young A | - |
dc.contributor.author | Kim, Je Eun | - |
dc.contributor.author | Heo, Seung Chul | - |
dc.contributor.author | Ahn, Young Joon | - |
dc.contributor.author | Hwang, Ki-Tae | - |
dc.contributor.author | Kim, Byeong Gwan | - |
dc.contributor.author | Lee, Kook Lae | - |
dc.contributor.author | Kim, Chul Woo | - |
dc.contributor.author | Kim, Woo Ho | - |
dc.contributor.author | Chang, Mee Soo | - |
dc.date.accessioned | 2009-10-29T04:40:35Z | - |
dc.date.available | 2009-10-29T04:40:35Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | J Korean Med Sci 2007; 22: 855-61 | en |
dc.identifier.issn | 1011-8934 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17982235 | - |
dc.identifier.uri | https://hdl.handle.net/10371/10895 | - |
dc.description.abstract | Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein-Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relationship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, beta-catenin, and E-cadherin immunohistochemistry, and clinicopathological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplasmic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with beta-catenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient's survival (p<0.05). In conclusion, beta-catenin activation through nuclear accumulation hardly occurred in EBV-infected gastric carcinomas. The combined immunoexpression pattern of beta-catenin and E-cadherin can be used as a prognostic marker in gastric carcinomas. | en |
dc.description.sponsorship | *This study was supported by a research grant funded
by the Seoul National University College of Medicine (2005). | en |
dc.language.iso | en | - |
dc.publisher | 대한의학회 = Korean Academy of Medical Science | en |
dc.subject | Stomach Neoplasms | en |
dc.subject | Herpesvirus 4, Human | en |
dc.subject | Beta Catenin | en |
dc.subject | Cadherins | en |
dc.subject | Prognosis | en |
dc.title | Epstein-Barr virus, beta-catenin, and E-cadherin in gastric carcinomas | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정인목 | - |
dc.contributor.AlternativeAuthor | 정중기 | - |
dc.contributor.AlternativeAuthor | 김영아 | - |
dc.contributor.AlternativeAuthor | 김제은 | - |
dc.contributor.AlternativeAuthor | 허승철 | - |
dc.contributor.AlternativeAuthor | 안영준 | - |
dc.contributor.AlternativeAuthor | 황기태 | - |
dc.contributor.AlternativeAuthor | 김병관 | - |
dc.contributor.AlternativeAuthor | 이국래 | - |
dc.contributor.AlternativeAuthor | 김철우 | - |
dc.contributor.AlternativeAuthor | 김우호 | - |
dc.contributor.AlternativeAuthor | 장미수 | - |
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