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Topical photodynamic therapy using intense pulsed light for treatment of actinic keratosis: clinical and histopathologic evaluation
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- Authors
- Issue Date
- 2005
- Publisher
- Blackwell Publishing
- Citation
- Dermatol Surg 2005;31-7
- Keywords
- Aminolevulinic Acid/*therapeutic use ; Keratosis/*drug therapy ; Photochemotherapy/*methods ; Photosensitizing Agents/*therapeutic use ; Treatment Outcome
- Abstract
- BACKGROUND: Photodynamic therapy (PDT) is suitable for the treatment of actinic keratosis, and, recently, topical PDT using intense pulsed light as a light source has been reported. However, evaluations of its therapeutic effects have been clinically based. OBJECTIVE: The objective of this study was to confirm the histopathologic resolution of actinic keratosis treated by topical PDT using intense pulsed light as a light source. METHODS: Twelve actinic keratosis lesions in seven patients were treated with 5-aminolevulinic acid-PDT using intense pulsed light as a light source. After a single treatment, the clinical response was assessed and histopathologic examinations were performed on clinically resolved lesions. RESULTS: Six of 12 (50%) lesions showed clinical clearance after a single treatment, but histologic examinations showed that only 5 of the 12 (42%) lesions had been removed. No complications, such as pigmentary changes or scarring, were observed. CONCLUSION: Intense pulsed light is potentially an effective light source for PDT. However, the determination of complete remission in actinic keratosis requires caution, and long-term follow-up or histologic confirmation may be required.
- ISSN
- 1076-0512 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15720093
https://hdl.handle.net/10371/10906
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