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Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice

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dc.contributor.authorKim, Hyeon Ho-
dc.contributor.authorLee, Min Jung-
dc.contributor.authorLee, Se Rah-
dc.contributor.authorKim, Kyu Han-
dc.contributor.authorCho, Kwang Hyun-
dc.contributor.authorEun, Hee Chul-
dc.contributor.authorChung, Jin Ho-
dc.date.accessioned2009-10-29T05:35:10Z-
dc.date.available2009-10-29T05:35:10Z-
dc.date.issued2005-
dc.identifier.citationMech Ageing Dev. 126, 1170-1177en
dc.identifier.issn0047-6374 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16118013-
dc.identifier.urihttps://hdl.handle.net/10371/10907-
dc.description.abstractSkin aging can be divided into intrinsic aging and photoaging. Sunlight is a major cause of photoaging, and is composed of ultraviolet (UV) and infrared (IR) radiation. Although the effects of UV radiation on skin aging have been widely studied, little is known about the biological effects of IR on the photoaging process in human skin. We found that chronic IR treatment induced wrinkles in hairless mice, and augments UV-induced wrinkle formation and UV-induced skin thickening in hairless mice. Histologically, we found that IR treatment augments UV-induced epidermal and dermal thickening, and that UV-induced increases of collagen and elastic fibers in dermis. Moreover, chronic IR treatment increased MMP-3 and MMP-13 mRNA expressions significantly in hairless mouse skin and augmented UV-induced MMP-3 and MMP-13 mRNA expressions and UV-induced MMP-2 and MMP-9 activities. From these results, we demonstrate that IR alone induces skin wrinkling and augments UV-induced wrinkle formation. Taken together, we suggest that IR plays an important role in the development of photoaging.en
dc.description.sponsorshipThis work was supported by a grant from the Korean
Health 21 R&D Project (02-PJ1-PG1-CH10-0001), Ministry
of Health & Welfare, Republic of Korea, and by a research
agreement with the Amore-Pacific Corporation.
en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectUltraviolet lighten
dc.subjectInfrared rayen
dc.subjectWrinkleen
dc.subjectHairless mouseen
dc.titleAugmentation of UV-induced skin wrinkling by infrared irradiation in hairless miceen
dc.typeArticleen
dc.contributor.AlternativeAuthor김현호-
dc.contributor.AlternativeAuthor이민정-
dc.contributor.AlternativeAuthor이세라-
dc.contributor.AlternativeAuthor김규한-
dc.contributor.AlternativeAuthor조광현-
dc.contributor.AlternativeAuthor은희철-
dc.contributor.AlternativeAuthor정진호-
dc.identifier.doi10.1016/j.mad.2005.06.003-
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