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Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo

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Authors
Kang, Sewon; Cho, Soyun; Chung, Jin Ho; Hammerberg, Craig; Fisher, Gary J.; Voorhees, John J.
Issue Date
2005
Publisher
American Society for Investigative Pathology
Citation
Am J Pathol 2005, 166:1691-1699
Keywords
Acne Vulgaris/*physiopathologyBlotting, WesternCytokines/metabolismExtracellular Matrix/metabolism/*pathologyGene Expression RegulationImmunohistochemistryInflammation/*physiopathologyMatrix Metalloproteinases/metabolismModels, BiologicalNF-kappa B/*metabolismProcollagen/metabolismRNA, Messenger/analysisReverse Transcriptase Polymerase Chain ReactionSignal Transduction/physiologySkin/metabolism/pathologyTranscription Factor AP-1/*metabolism
Abstract
Acne is the most common skin disease, causing significant psychosocial problems for those afflicted. Currently available agents for acne treatment, such as oral antibiotics and isotretinoin (Accutane), have limited use. Thus, development of novel agents to treat this disease is needed. However, the pathophysiology of acne inflammation is poorly understood. Before new therapeutic strategies can be devised, knowledge regarding molecular mechanisms of acne inflammation is required. We report here that transcription factors nuclear factor-kappaB and activator protein-1 are activated in acne lesions with consequent elevated expression of their target gene products, inflammatory cytokines and matrix-degrading metalloproteinases, respectively. These elevated gene products are molecular mediators of inflammation and collagen degradation in acne lesions in vivo. This new knowledge enables a rational strategy for development of pharmacological agents that can target the inflammation and matrix remodeling that occurs in severe acne.
ISSN
0002-9440 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15920154

http://hdl.handle.net/10371/10913
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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