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Design and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesion

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dc.contributor.authorKim, Tae-Il-
dc.contributor.authorJang, Jun-Hyeog-
dc.contributor.authorLee, Yong-Moo-
dc.contributor.authorRyu, In-Cheol-
dc.contributor.authorChung, Chong-Pyoung-
dc.contributor.authorHan, Soo-Boo-
dc.contributor.authorChoi, Sang-Mook-
dc.contributor.authorKu, Young-
dc.date.accessioned2009-10-29T22:12:38Z-
dc.date.available2009-10-29T22:12:38Z-
dc.date.issued2002-
dc.identifier.citationBiotechnol Letters 24, 2029-2033en
dc.identifier.issn0141-5492-
dc.identifier.urihttp://hdl.handle.net/10371/10924-
dc.description.abstractA synthetic oligopeptide, composed of Arg-Gly-Asp (RGD) and its synergistic Pro-His-Ser-Arg-Asn (PHSRN) motifs and a six glycines (G6) linker, promoted human osteoblast-like cell (MG-63) adhesion, spreading and mitogen-activated protein kinase (MAPK) activity in a similar manner to a positive fibronectin control. This synthetic oligopeptide may therefore be a useful osteo-inductive material.en
dc.description.sponsorshipThis work was supported by the Korean Science and
Engineering Foundation (KOSEF) through the Intellectual
Biointerface Engineering Center (IBEC) at
Seoul National University.
en
dc.language.isoen-
dc.publisherSpringer Verlagen
dc.subjectfibronectinen
dc.subjectmitogen-activated protein kinaseen
dc.subjectoligopeptidesen
dc.subjectosteoblast-like cellen
dc.titleDesign and biological activity of synthetic oligopeptides with Pro-His-Ser-Arg-Asn (PHSRN) and Arg-Gly-Asp (RGD) motifs for human osteoblast-like cell (MG-63) adhesionen
dc.typeArticleen
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor장준형-
dc.contributor.AlternativeAuthor이용무-
dc.contributor.AlternativeAuthor류인철-
dc.contributor.AlternativeAuthor정종평-
dc.contributor.AlternativeAuthor한수부-
dc.contributor.AlternativeAuthor최상묵-
dc.contributor.AlternativeAuthor구영-
dc.identifier.doi10.1023/A:1021368519336-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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