Publications
Detailed Information
Impact of low high-density lipoprotein-cholesterol level on 2-year clinical outcomes after acute myocardial infarction in patients with diabetes mellitus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Cho, Sang-A | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Bae, Jang-Ho | - |
dc.contributor.author | Choi, Dong-Ju | - |
dc.contributor.author | Ahn, Young-Keun | - |
dc.contributor.author | Park, Jong-Seon | - |
dc.contributor.author | Choi, Rak-Kyeong | - |
dc.contributor.author | Choi, Donghoon | - |
dc.contributor.author | Kim, Joon-Hong | - |
dc.contributor.author | Han, Kyoo-Rok | - |
dc.contributor.author | Park, Hun-Sik | - |
dc.contributor.author | Choi, So-Yeon | - |
dc.contributor.author | Yoon, Jung-Han | - |
dc.contributor.author | Kwon, Hyeon-Cheol | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Hwang, Kyung-Kuk | - |
dc.contributor.author | Jung, Kyung-Tae | - |
dc.contributor.author | Oh, Seok-Kyu | - |
dc.contributor.author | Lee, Jae-Hwan | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Kim, Kee-Sik | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.date.accessioned | 2017-03-16T06:42:16Z | - |
dc.date.available | 2017-03-16T15:49:46Z | - |
dc.date.issued | 2016-11-18 | - |
dc.identifier.citation | Lipids in Health and Disease, 15(1):197 | ko_KR |
dc.identifier.uri | https://hdl.handle.net/10371/109756 | - |
dc.description.abstract | Background
It is still unclear whether low high-density lipoprotein cholesterol (HDL-C) affects cardiovascular outcomes after acute myocardial infarction (AMI), especially in patients with diabetes mellitus. Methods A total of 984 AMI patients with diabetes mellitus from the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND) Korean multicenter registry were divided into two groups based on HDL-C level on admission: normal HDL-C group (HDL-C ≥ 40mg/dL, n = 519) and low HDL-C group (HDL-C < 40mg/dL, n = 465). The primary endpoint was 2-year major adverse cardiovascular events (MACE), defined as a composite of cardiac death, non-fatal myocardial infarction (MI), and target vessel revascularization (TVR). Results The median follow-up duration was 730days. The 2-year MACE rates were significantly higher in the low HDL-C group than in the normal HDL-C group (MACE, 7.44% vs. 3.49%, p = 0.006; cardiac death, 3.72% vs. 0.97%, p = 0.004; non-fatal MI, 1.75% vs. 1.55%, p = 0.806; TVR, 3.50% vs. 0.97%, p = 0.007). Kaplan-Meier analysis revealed that the low HDL-C group had a significantly higher incidence of MACE compared to the normal HDL-C group (log-rank p = 0.013). After adjusting for conventional risk factors, Cox proportional hazards analysis suggested that low HDL-C was an independent risk predictor for MACE (hazard ratio [HR] 3.075, 95% confidence interval [CI] 1.034-9.144, p = 0.043). Conclusions In patients with diabetes mellitus, low HDL-C remained an independent risk predictor for MACE after adjusting for multiple risk factors during 2-year follow-up of AMI. Trial registration This study was the sub-analysis of the prospective multi-center registry of DIAMOND (Diabetic acute myocardial infarction Disease) in Korea. This is the observational study supported by Bayer HealthCare, Korea. Study number is 15614. First patient first visit was 02 April 2010 and last patient last visit was 09 December 2013. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | High-density lipoprotein cholesterol | ko_KR |
dc.subject | Major adverse cardiovascular events | ko_KR |
dc.subject | Acute myocardial infarction | ko_KR |
dc.subject | Diabetes mellitus | ko_KR |
dc.title | Impact of low high-density lipoprotein-cholesterol level on 2-year clinical outcomes after acute myocardial infarction in patients with diabetes mellitus | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 주형준 | - |
dc.contributor.AlternativeAuthor | 조상아 | - |
dc.contributor.AlternativeAuthor | 홍순준 | - |
dc.contributor.AlternativeAuthor | 허승호 | - |
dc.contributor.AlternativeAuthor | 배장호 | - |
dc.contributor.AlternativeAuthor | 최동주 | - |
dc.contributor.AlternativeAuthor | 안영근 | - |
dc.contributor.AlternativeAuthor | 박종선 | - |
dc.contributor.AlternativeAuthor | 최락경 | - |
dc.contributor.AlternativeAuthor | 최동훈 | - |
dc.contributor.AlternativeAuthor | 김준홍 | - |
dc.contributor.AlternativeAuthor | 한규록 | - |
dc.contributor.AlternativeAuthor | 박훈식 | - |
dc.contributor.AlternativeAuthor | 최소연 | - |
dc.contributor.AlternativeAuthor | 윤정한 | - |
dc.contributor.AlternativeAuthor | 권현철 | - |
dc.contributor.AlternativeAuthor | 라승운 | - |
dc.contributor.AlternativeAuthor | 황경국 | - |
dc.contributor.AlternativeAuthor | 정경태 | - |
dc.contributor.AlternativeAuthor | 오석규 | - |
dc.contributor.AlternativeAuthor | 이재환 | - |
dc.contributor.AlternativeAuthor | 신은석 | - |
dc.contributor.AlternativeAuthor | 김기식 | - |
dc.contributor.AlternativeAuthor | 김효수 | - |
dc.contributor.AlternativeAuthor | 임도선 | - |
dc.identifier.doi | 10.1186/s12944-016-0374-5 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s). | - |
dc.date.updated | 2017-01-06T10:28:39Z | - |
- Appears in Collections:
- Files in This Item:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.