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Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage

DC Field Value Language
dc.contributor.authorMin, Hyunjung-
dc.contributor.authorJang, Yong Ho-
dc.contributor.authorCho, Ik-Hyun-
dc.contributor.authorYu, Seong-Woon-
dc.contributor.authorLee, Sung Joong-
dc.date.accessioned2017-03-17T08:10:56Z-
dc.date.available2017-03-17T17:50:18Z-
dc.date.issued2016-04-19-
dc.identifier.citationMolecular Brain, 9(1):42ko_KR
dc.identifier.urihttp://hdl.handle.net/10371/109825-
dc.description.abstractBackground
Intracerebral hemorrhage (ICH) is one of the major causes of stroke. After onset of ICH, massive infiltration of macrophages is detected in the peri-hematoma regions. Still, the function of these macrophages in ICH has not been completely elucidated.

Results
In a collagenase-induced ICH model, CX3CR1+ macrophages accumulated in the peri-hematoma region. Characterization of these macrophages revealed expression of alternatively activated (M2) macrophage markers. In the macrophage-depleted mice, ICH-induced brain lesion volume was larger and neurological deficits were more severe compared to those of control mice, indicating a protective role of these macrophages in ICH. In the ICH-injured brain, mannose receptor-expressing macrophages increased at a delayed time point after ICH, indicating M2 polarization of the brain-infiltrating macrophages in the brain microenvironment. To explore this possibility, bone marrow-derived macrophages (BMDM) were co-cultured with mouse brain glial cells and then tested for activation phenotype. Upon co-culture with glia, the number of mannose receptor-positive M2 macrophages was significantly increased. Furthermore, treatment with glia-conditioned media increased the number of BMDM of M2 phenotype.

Conclusions
In this study, our data suggest that brain-infiltrating macrophages after ICH are polarized to the M2 phenotype by brain glial cells and thereby contribute to recovery from ICH injury.
ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectImmune responseko_KR
dc.subjectMacrophagesko_KR
dc.subjectWound healingko_KR
dc.titleAlternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhageko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor민현정-
dc.contributor.AlternativeAuthor장용호-
dc.contributor.AlternativeAuthor조익현-
dc.contributor.AlternativeAuthor유성운-
dc.contributor.AlternativeAuthor이성중-
dc.identifier.doi10.1186/s13041-016-0225-3-
dc.language.rfc3066en-
dc.rights.holderMin et al.-
dc.date.updated2017-01-06T10:36:14Z-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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