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Identifying molecular subtypes related to clinicopathologic factors in pancreatic cancer

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Authors
Kim, Shinuk; Kang, Mee Joo; Lee, Seungyeoun; Bae, Soohyun; Han, Sangjo; Jang, Jin-Young; Park, Taesung
Issue Date
2014-12-11
Publisher
BioMed Central
Citation
BioMedical Engineering OnLine, 13(Suppl 2):S5
Abstract
Background
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal tumors and usually presented with locally advanced and distant metastasis disease, which prevent curative resection or treatments. In this regard, we considered identifying molecular subtypes associated with clinicopathological factor as prognosis factors to stratify PDAC for appropriate treatment of patients.

Results
In this study, we identified three molecular subtypes which were significant on survival time and metastasis. We also identified significant genes and enriched pathways represented for each molecular subtype. Considering R0 resection patients included in each subtype, metastasis and survival times are significantly associated with subtype 1 and subtype 2.

Conclusions
We observed three PDAC molecular subtypes and demonstrated that those subtypes were significantly related with metastasis and survival time. The study may have utility in stratifying patients for cancer treatment.
Language
English
URI
http://hdl.handle.net/10371/109856
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College of Natural Sciences (자연과학대학)Dept. of Statistics (통계학과)Journal Papers (저널논문_통계학과)
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