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High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae

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Authors
Lee, Hun-Goo; Lee, Hyo-Soo; Jeon, Sang-Hoon; Chung, Tae-Hoon; Lim, Young-Sung; Huh, Won-Ki
Issue Date
2008-01-03
Publisher
BioMed Central
Citation
Genome Biology, 9(1):R2
Abstract
We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.
Language
English
URI
http://hdl.handle.net/10371/109876
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College of Natural Sciences (자연과학대학)Dept. of Biological Sciences (생명과학부)Journal Papers (저널논문_생명과학부)
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