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High-resolution analysis of condition-specific regulatory modules in Saccharomyces cerevisiae
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- Authors
- Issue Date
- 2008-01-03
- Publisher
- BioMed Central
- Citation
- Genome Biology, 9(1):R2
- Abstract
- We present an approach for identifying condition-specific regulatory modules by using separate units of gene expression profiles along with ChIP-chip and motif data from Saccharomyces cerevisiae. By investigating the unique and common features of the obtained condition-specific modules, we detected several important properties of transcriptional network reorganization. Our approach reveals the functionally distinct coregulated submodules embedded in a coexpressed gene module and provides an effective method for identifying various condition-specific regulatory events at high resolution.
- Language
- English
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