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Illuminating the physiology of extracellular vesicles

Cited 33 time in Web of Science Cited 32 time in Scopus
Authors
Choi, Hongyoon; Lee, Dong Soo
Issue Date
2016-04-16
Publisher
BioMed Central
Citation
Stem Cell Research & Therapy, 7(1):55
Keywords
Extracellular vesicleExosomeMicrovesicleImagingIn vivo distribution
Abstract
Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. They have pathophysiologic roles in cancer metastasis, neurodegenerative diseases, and inflammation. Extracellular vesicles also show promise as emerging therapeutics, with understanding of their physiology including targeting, distribution, and clearance therefore becoming an important issue. Here, we review recent advances in methods for tracking and imaging extracellular vesicles in vivo and critically discuss their systemic distribution, targeting, and kinetics based on up-to-date evidence in the literature.
Language
English
URI
http://hdl.handle.net/10371/109957
DOI
https://doi.org/10.1186/s13287-016-0316-1
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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