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Application of structural equation models to construct genetic networks using differentially expressed genes and single-nucleotide polymorphisms

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Authors
Lee, Seungmook; Jhun, Mina; Lee, Eun-Kyung; Park, Taesung
Issue Date
2007-12-18
Publisher
BioMed Central
Citation
BMC Proceedings, 1(Suppl 1):S76
Abstract
Understanding the genetic basis of human variation is an important goal of biomedical research. In this study, we used structural equation models (SEMs) to construct genetic networks to model how specific single-nucleotide polymorphisms (SNPs) from two genes known to cause acute myeloid leukemia (AML) by somatic mutation, runt-related transcription factor 1 (RUNX1) and ets variant gene 6 (ETV6), affect expression levels of other genes and how RUNX1 and ETV6 are related to each other. The SEM approach allows us to compare several candidate models from which an explanatory genetic network can be constructed.
Language
English
URI
http://hdl.handle.net/10371/109992
DOI
https://doi.org/10.1186/1753-6561-1-S1-S76
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College of Natural Sciences (자연과학대학)Dept. of Statistics (통계학과)Journal Papers (저널논문_통계학과)
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