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Enhanced Mn-SOD immunoreactivity in the dopaminergic neurons of long-evans cinnamon rats

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Authors
Kim, Dong Woon; Ahn, Tae-Beom; Kim, Jong Min; Jeon, Gye Sun; Seo, Je Hoon; Jeon, Beom S; Cho, Sa Sun
Issue Date
2005
Publisher
Springer Verlag
Citation
Neurochem. Res. 30(4):475-478
Keywords
Copperoxidative stresssubstantia nigraWilson’s disease
Abstract
The abundance of cellular superoxide dismutase (Mn-SOD) was examined immunocytochemically in different regions of the brain of Long-Evans Cinnamon (LEC) rats at 4 and 50 weeks of age. When all animals develop chronic hepatitis, the substantia nigra and striatum showed a marked increase in Mn-SOD immunoreactivity versus Long-Evans agouti (LEA) rats of the same age. Mn-SOD was localized predominantly in dopaminergic neurons. The elevation of Mn-SOD level in the dopaminergic neurons of LEC rats may reflect the oxidative stress caused by copper accumulation in this brain area. Our data suggest that LEC rats may contribute to the mechanistic study of neurological manifestations in nigro-striatal dopaminergic system of Wilson's disease.
ISSN
0364-3190 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16076018

http://hdl.handle.net/10371/11034
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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