Prevention of UV radiation-induced premature skin aging in hairless mice by the novel compound Melanocin A

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Park, Chi-Hyun; Lee, Min Jung; Kim, Jong-Pyung; Yoo, Ick Dong; Chung, Jin Ho
Issue Date
Blackwell Publishing
Photochem. Photobiol. 82, 574-578
Cell LineCyanides/*pharmacologyDose-Response Relationship, DrugEurotiales/*chemistryKeratinocytes/cytology/*drug effects/physiologyMatrix Metalloproteinase 2/genetics/metabolismMatrix Metalloproteinase 9/genetics/metabolismMice, HairlessPhototherapy/methodsProteins/analysis/metabolismRNA, Messenger/analysis/metabolismSkin Aging/*drug effects/physiology/radiation effectsTime FactorsUltraviolet Rays/*adverse effects
Repetitive exposure of the skin to UV radiation induces various harmful changes, such as thickening, wrinkle formation, inflammation and carcinogenesis. A variety of natural compounds and synthetic compounds have been studied to determine whether they can prevent UV-induced harmful effects. In this study, we investigated the effect of a novel compound, Melanocin A, which was isolated from Eupenicillium shearii F80695, on UV-induced premature skin aging. First, we studied the effect of Melanocin A on UV-induced matrix metalloproteinase (MMP)-9 expression in an immortalized human keratinocyte cell line, HaCaT, in vitro. Acute UV irradiation induced MMP-9 expression at both the mRNA and protein levels and Melanocin A suppressed this expression in a dose-dependent manner. We then investigated the effect of Melanocin A on UV-induced skin changes in hairless mice in vivo. Chronic exposure of hairless mouse dorsal skin to UV increased skin thickness and induced wrinkle formation and the gelatinase activities of MMP-2 and MMP-9. Moreover, Melanocin A significantly suppressed UV-induced morphologic skin changes and MMP-2 and MMP-9 expression. Taken together, these results show that Melanocin A can prevent the harmful effects of UV that lead to skin aging. Therefore, we suggest that Melanocin A should be viewed as a potential therapeutic agent for preventing and/or treating premature skin aging.
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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