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G-CSF protects human cerebral hybrid neurons against in vitro ischemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Kang, Lami | - |
dc.contributor.author | Kim, Seung U. | - |
dc.contributor.author | Kim, Manho | - |
dc.contributor.author | Roh, Jae-Kyu | - |
dc.date.accessioned | 2009-11-04T04:16:18Z | - |
dc.date.available | 2009-11-04T04:16:18Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Neurosci. Lett. 394 (2006) 168-173 | en |
dc.identifier.issn | 0304-3940 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16298488 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11094 | - |
dc.description.abstract | Granulocyte colony-stimulating factor (G-CSF) protects neurons against experimental focal cerebral ischemia. However, its neuroprotective effect on human brain is unknown. We sought to determine whether G-CSF can protect the human cerebral neurons in vitro. Human cerebral-neuroblastoma hybrid cell line (A1) was exposed to oxygen and glucose deprivation with or without G-CSF. G-CSF promoted cell survival and decreased cytotoxicity effectively at 25 ng/ml. G-CSF reduced early apoptotic (annexin V+/PI-), and late apoptotic or necrotic (annexin V+/PI+) cells, and decreased active caspase-3 immunoreactivity. G-CSF could protect human cerebral neurons following in vitro ischemia. | en |
dc.description.sponsorship | This study was supported by the 21st Century Frontier
Research Fund of Ministry of Science & Technology (SC3060) and by grant from the Seoul National University Hospital, Samsung Research Fund (21-2003-002-0), Republic of Korea. | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | G-CSF | en |
dc.subject | Ischemia | en |
dc.subject | Neuronal death | en |
dc.subject | Neuroprotection | en |
dc.subject | G-CSFR | en |
dc.subject | STAT3 | en |
dc.title | G-CSF protects human cerebral hybrid neurons against in vitro ischemia | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정근화 | - |
dc.contributor.AlternativeAuthor | 주건 | - |
dc.contributor.AlternativeAuthor | 이순태 | - |
dc.contributor.AlternativeAuthor | 강라미 | - |
dc.contributor.AlternativeAuthor | 김만호 | - |
dc.contributor.AlternativeAuthor | 노재규 | - |
dc.identifier.doi | 10.1016/j.neulet.2005.10.040 | - |
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