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Correlation of coronary and cerebral atherosclerosis: difference between extracranial and intracranial arteries

Cited 45 time in Web of Science Cited 2 time in Scopus
Authors
Bae, Hee-Joon; Yoon, Byung-Woo; Kang, Dong-Wha; Koo, Ja-Seong; Lee, Seung-Hoon; Kim, Ki-Bong; Lee, Juneyoung; Roh, Jae-Kyu
Issue Date
2006
Publisher
Karger
Citation
Cerebrovasc Dis 2006;21:112-119
Keywords
Intracranial atherosclerosisCoronary atherosclerosisCarotid atherosclerosisCoronary artery bypass
Abstract
BACKGROUND: A difference with regard to the correlation with coronary atherosclerosis (CAS) between extracranial carotid atherosclerosis (ECAS) and intracranial cerebral atherosclerosis (ICAS) has been assumed but not proven clearly by direct comparison within the same population. METHODS: A consecutive series of 246 patients undergoing coronary artery bypass graft surgery were reviewed. The severity of CAS was estimated as a CAS score based on coronary angiography. The presence of ECAS and ICAS was screened by transcranial Doppler and carotid duplex sonography, and confirmed by magnetic resonance angiography. RESULTS: The CAS scores in patients with ECAS were observed to be higher than those in patients without ECAS (10.62+/- 4.80 vs. 9.45+/- 4.25; p=0.054 on the Mann-Whitney U test). The difference in CAS scores was smaller between patients with and without ICAS (10.41+/- 4.44 vs. 9.66+/- 4.49; p=0.201). Similar patterns were observed on comparing the correlation of ECAS and ICAS with a quartile of the CAS score. An advanced CAS, which was generated by collapsing the quartiles of the CAS score into 75th percentile or less and more than the 75th percentile, was significantly associated with ECAS, but not with ICAS. These associations remained unchanged after adjustments had been made for age, sex, hypertension, diabetes mellitus, hyperlipidemia, smoking and a history of stroke or transient ischemic attack. CONCLUSIONS: This study suggests that the correlation of CAS with ECAS is stronger than that of CAS with ICAS, and this difference is independent of the classic risk factors for atherosclerosis.
ISSN
1015-9770 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16340186

http://hdl.handle.net/10371/11111
DOI
https://doi.org/10.1159/000090209
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Neurology (신경과학교실)Journal Papers (저널논문_신경과학교실)
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