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Infrared exposure induces an angiogenic switch in human skin that is partially mediated by heat

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dc.contributor.authorKim, M-S.-
dc.contributor.authorKim, Y.K.-
dc.contributor.authorCho, K.H.-
dc.contributor.authorChung, J.H.-
dc.date.accessioned2009-11-04T07:50:42Z-
dc.date.available2009-11-04T07:50:42Z-
dc.date.issued2006-
dc.identifier.citationBr J Dermatol 2006; 155:1131-8en
dc.identifier.issn0007-0963 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17107379-
dc.identifier.urihttp://hdl.handle.net/10371/11143-
dc.description.abstractBACKGROUND: Angiogenesis plays an important role in physiological and pathological conditions of the skin. Although acute ultraviolet-induced skin angiogenesis has been investigated, little is known about the distinct effects of acute infrared (IR) radiation on angiogenesis in human skin. OBJECTIVES: To elucidate the molecular regulation of the angiogenic switch by acute near-IR radiation or by a single heat treatment in human skin in vivo. METHODS: We subjected 16 healthy volunteers to near-IR irradiation (six minimal heating doses) and 14 healthy volunteers to heat treatment (43 degrees C for 90 min), and skin specimens were obtained by punch biopsy for immunohistochemical, Western blot and reverse transcription-polymerase chain reaction analyses. RESULTS: We observed that CD31-stained vessels in the upper dermis were increased after acute near-IR exposure, and that this was associated with the upregulation of vascular endothelial growth factor (VEGF) and the downregulation of thrombospondin (TSP)-2. During the application of near-IR to buttock skin, skin temperatures immediately increased from 32 degrees C up to 42 degrees C, as measured using a digital thermometer. Moreover, the expression of inducible heat shock protein 70 was increased after near-IR irradiation in human skin. Therefore, we investigated the effects of a single heat treatment on angiogenesis and on the expression of VEGF and TSP-2 in skin, and found that vascularization and VEGF expression were increased, whereas TSP-2 expression was reduced. CONCLUSIONS: Our results suggest that IR radiation plays an important role in skin angiogenesis via regulation of the balance between the angiogenic inducer VEGF and the angiogenic inhibitor TSP-2, and that IR-induced skin angiogenesis might be partially caused by the effects of heat in human skin in vivo.en
dc.description.sponsorshipThis work was supported by a Korea Research Foundation
Grant (KRF-2003-015-E00243) and by a research agreement
with Estee Lauder (Melville, NY).
en
dc.language.isoen-
dc.publisherBlackwell Publishingen
dc.subjectangiogenesisen
dc.subjectheaten
dc.subjectinfrareden
dc.subjectthrombospondin-2en
dc.subjectvascular endothelial growth factoren
dc.titleInfrared exposure induces an angiogenic switch in human skin that is partially mediated by heaten
dc.typeArticleen
dc.identifier.doi10.1111/j.1365-2133.2006.07510.x-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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