3T 1H-MR spectroscopy in grading of cerebral gliomas: comparison of short and intermediate echo time sequences

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Kim, J. H.; Chang, K. H.; Na, D. G.; Song, I. C.; Kwon, B. J.; Han, M. H.; Kim, K.
Issue Date
American Society of Neuroradiology
AJNR Am J Neuroradiol 2006;27:1412-8
Aspartic Acid/analogs & derivatives/analysisBrain Neoplasms/*diagnosisCholine/analysisCreatine/analysisEcho-Planar Imaging/methodsGlioma/*diagnosisHydrogenImage Enhancement/methodsInositol/analysisLactates/analysisLipids/analysisMagnetic Resonance Spectroscopy/*methodsPhosphocreatine/analysisTime Factors
BACKGROUND AND PURPOSE: Echo time (TE) can have a large influence on the spectra in proton MR spectroscopy ((1)H-MR spectroscopy). The purpose of this study was to comparatively assess the diagnostic value of 3T single-voxel (1)H-MR spectroscopy with short or intermediate TEs in grading cerebral gliomas. METHODS: Single voxel (1)H-MR spectroscopy was performed at 3T in 35 patients with cerebral glioma. The spectra were obtained with both short (35 ms) and intermediate TEs (144 ms). Metabolite ratios of choline (Cho)/creatine (Cr), Cho/N-acetylaspartate (NAA), lipid and lactate (LL)/Cr and myo-inositol (mIns)/Cr were calculated and compared between short and intermediate TEs in each grade. After receiver operating characteristic curve analysis, diagnostic accuracy for each TE in differentiating high-grade glioma from low-grade glioma was compared. RESULTS: At short TE, Cho/Cr and Cho/NAA ratios were significantly lower, and LL/Cr and mIns/Cr were significantly higher, compared with those at intermediate TE, regardless of tumor grade. Lactate inversion at intermediate TE was found in only 2 patients. At both TEs, there were significant differences in Cho/Cr and LL/Cr ratios between low- and high-grade gliomas. Diagnostic accuracy was slightly higher at short TE alone or combined with intermediate TE than intermediate TE alone (85.7% versus 82.9%). CONCLUSION: Metabolite ratios were significantly different between short and intermediate TE. Cho/Cr and LL/Cr ratios at either TE were similarly useful in differentiating high-grade gliomas from low-grade gliomas. If only a single spectroscopic sequence can be acquired, short TE seems preferable because of poor lactate inversion at intermediate TE on 3T single-voxel (1)H-MR spectroscopy.
0195-6108 (Print)
1936-959X (Electronic)
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College of Medicine/School of Medicine (의과대학/대학원)Radiology (영상의학전공)Journal Papers (저널논문_영상의학전공)
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