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Factors affecting the long-term outcomes of idiopathic membranous nephropathy

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Authors
Huh, Hyuk; Lee, Hajeong; Lee, Jung Pyo; Kim, Dong Ki; Oh, Sohee; Oh, Yun Kyu; Kim, Yon Su; Lim, Chun Soo
Issue Date
2017-03-27
Publisher
BioMed Central
Citation
BMC Nephrology, 18(1):104
Keywords
Idiopathic membranous nephropathyNephrotic syndromePrognosisProteinuriaRenal survival
Abstract
Background
We attempted to describe the clinical features and determine the factors associated with renal survival in idiopathic membranous nephropathy (iMN) patients with nephrotic syndrome (NS) and to determine the factors associated with spontaneous complete remission (sCR) and progression to NS in iMN patients with subnephrotic proteinuria.

Methods
This retrospective study involved 166 iMN patients with NS and 65 patients with subnephrotic proteinuria. The primary end point was a doubling of serum creatinine or initiation of dialysis. In patients with subnephrotic proteinuria, we determined the factors associated with sCR and factors associated with progression to NS.

Results
Remission of NS was achieved in 125 out of 166 patients (75.3%). Of those who reached remission, 26 patients (20.8%) experienced relapse that was followed by second remission. The relapse or persistence of proteinuria was associated with the primary end points (hazard ratio [HR] = 12.40, P = 0.037, HR = 173, P < 0.001, respectively). In patients with subnephrotic proteinuria, sCR occurred in 35.4% of the patients. The patients with sCR had lower proteinuria and serum creatinine levels and higher serum albumin concentrations at baseline. The serum albumin level at diagnosis was a prognostic factor for progression to NS (Odds ratio [OR] = 0.015, P < 0.001).

Conclusions
The occurrence of relapse or persistence of proteinuria had negative effects on renal survival in iMN patients with NS, and low serum albumin levels at baseline were associated with non-achievement of sCR and progression to NS.
Language
English
URI
http://hdl.handle.net/10371/112411
DOI
https://doi.org/10.1186/s12882-017-0525-6
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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