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Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression

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Authors
Kim, Jeong Hun; Kim, Ki Hyun; Kim, Jin Hyoung; Yu, Young Suk; Kim, Young-Myeong; Kim, Kyu-Won; Kwon, Ho Jeong
Issue Date
2007-09-07
Publisher
Academic Press
Citation
Biochem Biophys Res Commun. 2007 Nov 3;362(4):848-52. Epub 2007 Aug 28.
Keywords
AnimalsCDC2 Protein Kinase/*metabolismCell Cycle/drug effectsDisease Models, AnimalDose-Response Relationship, DrugDown-Regulation/drug effectsHumansInfant, NewbornIsoflavones/*therapeutic useMiceMice, Inbred C57BLRetinal Neovascularization/*drug therapy/*metabolism/pathologyRetinopathy of Prematurity/*drug therapy/*metabolism/pathology
Abstract
Neovascularization in the eye is the most common cause of blindness in all age groups; retinopathy of prematurity (ROP), diabetic retinopathy, and age-related macular degeneration. Despite current advances in surgical treatments, ROP remains as the most serious problem of vision loss in children. Here, we report that homoisoflavanone, a natural product from Cremastra appendiculata, significantly reduces retinal neovascularization in a mouse model of ROP. Homoisoflavanone inhibited the cell growth of HUVECs, but its cytotoxic effect was not observed in a concentration range of 1-20 microM. HUVECs population gradually increased in G2/M phase and reduced in G0/G1 and S phases after exposure to the compound. Homoisoflavanone decreased the level of cdc2 expression whereas the level of p21WAF1 expression was increased in a dose-dependent manner. These data demonstrate that homoisoflavanone could inhibit retinal neovascularization and be applied in the treatment of other vasoproliferative retinopathies.
ISSN
0006-291X (Print)
Language
English
URI
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4PHSK6Y-1&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=ae1d619d63f7d9cf3bc72859edadc462

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17803958

http://hdl.handle.net/10371/11568
DOI
https://doi.org/10.1016/j.bbrc.2007.08.100
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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