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Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial
DC Field | Value | Language |
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dc.contributor.author | Jeong, Seung-Yong | en |
dc.contributor.author | Park, Ji Won | - |
dc.contributor.author | Nam, Byung Ho | - |
dc.contributor.author | Kim, Sohee | - |
dc.contributor.author | Kang, Sung-Bum | - |
dc.contributor.author | Lim, Seok-Byung | - |
dc.contributor.author | Choi, Hyo Seong | - |
dc.contributor.author | Kim, Duck-Woo | - |
dc.contributor.author | Chang, Hee Jin | - |
dc.contributor.author | Kim, Dae Yong | - |
dc.contributor.author | Jung, Kyung Hae | - |
dc.contributor.author | Kim, Tae-You | - |
dc.contributor.author | Kang, Gyeong Hoon | - |
dc.contributor.author | Chie, Eui Kyu | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Sohn, Dae Kyung | - |
dc.contributor.author | Kim, Dae-Hyun | - |
dc.contributor.author | Kim, Jae-Sung | - |
dc.contributor.author | Oh, Jae Hwan | - |
dc.date.accessioned | 2017-04-19T00:19:41Z | - |
dc.date.available | 2017-12-27T13:54:20Z | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | The Lancet Oncology, Vol.15, pp. 767-774 | - |
dc.identifier.issn | 1470-2045 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116875 | - |
dc.description.abstract | Background Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. We aimed to compare survival outcomes of laparoscopic surgery with open surgery for patients with mid-rectal or low-rectal cancer. Methods The Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial was an open-label, non-inferiority, randomised controlled trial done between April 4, 2006, and Aug 26, 2009, at three centres in Korea. Patients (aged 18-80 years) with cT3N0-2M0 mid-rectal or low-rectal cancer who had received preoperative chemoradiotherapy were randomly assigned (1:1) to receive either open or laparoscopic surgery. Randomisation was stratified by sex and preoperative chemotherapy regimen. Investigators were masked to the randomisation sequence; patients and clinicians were not masked to the treatment assignments. The primary endpoint was 3 year disease-free survival, with a non-inferiority margin of 15%. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT0040951. Findings We randomly assigned 340 patients to receive either open surgery (n=170) or laparoscopic surgery (n=170). 3 year disease-free survival was 72.5% (95% CI 65.0-78.6) for the open surgery group and 79.2% (72.3-84.6) for the laparoscopic surgery group, with a difference that was lower than the prespecified non-inferiority margin (-6.7%, 95% CI -15.8 to 2.4; p<0.0001). 25 (15%) patients died in the open group and 20 (12%) died in the laparoscopic group. No deaths were treatment related. Interpretation Our results show that laparoscopic resection for locally advanced rectal cancer after preoperative chemoradiotherapy provides similar outcomes for disease-free survival as open resection, thus justifying its use. | en |
dc.description.sponsorship | The COREAN trial was supported by a grant from the National Cancer Centre (number 1210160). | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | en |
dc.subject | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | en |
dc.subject | 의약학 | en |
dc.title | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 정승용 | - |
dc.contributor.AlternativeAuthor | 박지원 | - |
dc.contributor.AlternativeAuthor | 남병호 | - |
dc.contributor.AlternativeAuthor | 김소희 | - |
dc.contributor.AlternativeAuthor | 강성범 | - |
dc.contributor.AlternativeAuthor | 임석병 | - |
dc.contributor.AlternativeAuthor | 최효성 | - |
dc.contributor.AlternativeAuthor | 김덕우 | - |
dc.contributor.AlternativeAuthor | 장희진 | - |
dc.contributor.AlternativeAuthor | 김대용 | - |
dc.contributor.AlternativeAuthor | 정경해 | - |
dc.contributor.AlternativeAuthor | 김태유 | - |
dc.contributor.AlternativeAuthor | 강경훈 | - |
dc.contributor.AlternativeAuthor | 채의규 | - |
dc.contributor.AlternativeAuthor | 김선영 | - |
dc.contributor.AlternativeAuthor | 손대경 | - |
dc.contributor.AlternativeAuthor | 김대현 | - |
dc.contributor.AlternativeAuthor | 김재성 | - |
dc.contributor.AlternativeAuthor | 오재환 | - |
dc.identifier.doi | 10.1016/S1470-2045(14)70205-0 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201400342 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A078927 | - |
dc.description.srnd | CITE_RATE:24.69 | - |
dc.description.srnd | DEPT_NM:의학과 | - |
dc.description.srnd | EMAIL:syjeong@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.identifier.srnd | T201400342 | - |
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