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Imaging Single-mRNA Localization and Translation in Live Neurons
Cited 15 time in
Web of Science
Cited 15 time in Scopus
- Authors
- Issue Date
- 2016-12
- Publisher
- KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
- Citation
- MOLECULES AND CELLS, Vol.39 No.12, pp.841-846
- Abstract
- Local protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA molecules is particularly advantageous to dissect the highly heterogeneous and dynamic nature of messenger ribonucleoprotein (mRNP) complexes in neurons. Here, we review recent advances in the study of mRNA localization and translation in live neurons using novel techniques for single-RNA imaging.
- ISSN
- 1016-8478
- Language
- English
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