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Imaging Single-mRNA Localization and Translation in Live Neurons

DC Field Value Language
dc.contributor.authorLee, Byung Hun-
dc.contributor.authorBae, Seong-Woo-
dc.contributor.authorShim, Jaeyoun Jay-
dc.contributor.authorPark, Sung Young-
dc.contributor.authorPark, Hye Yoon-
dc.date.accessioned2017-04-19T00:19:48Z-
dc.date.available2017-11-10T11:08:08Z-
dc.date.issued2016-12-
dc.identifier.citationMolecules and Cells, Vol.39 No.12, pp. 841-846-
dc.identifier.issn1016-8478-
dc.identifier.urihttp://hdl.handle.net/10371/116885-
dc.description.abstractLocal protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA molecules is particularly advantageous to dissect the highly heterogeneous and dynamic nature of messenger ribonucleoprotein (mRNP) complexes in neurons. Here, we review recent advances in the study of mRNA localization and translation in live neurons using novel techniques for single-RNA imaging.-
dc.language.isoenen
dc.publisherKorean Society for Molecular and Cellular Biologyen
dc.subjectImaging Single-mRNA Localization and Translation in Live Neuronsen
dc.subject자연과학en
dc.subjectlive-cell imaging-
dc.subjectlocal translation-
dc.subjectMS2-GFP-
dc.subjectRNA localization-
dc.subjectsingle-molecule imaging-
dc.titleImaging Single-mRNA Localization and Translation in Live Neuronsen
dc.typeArticleen
dc.contributor.AlternativeAuthor이병훈-
dc.contributor.AlternativeAuthor배성우-
dc.contributor.AlternativeAuthor심재윤-
dc.contributor.AlternativeAuthor박혜윤-
dc.author.alternative박성영-
dc.identifier.doi10.14348/molcells.2016.0277-
dc.description.srndOAIID:RECH_ACHV_DSTSH_NO:T201619561-
dc.description.srndRECH_ACHV_FG:RR00200001-
dc.description.srndADJUST_YN:-
dc.description.srndEMP_ID:A079734-
dc.description.srndCITE_RATE:2.67-
dc.description.srndDEPT_NM:물리·천문학부-
dc.description.srndEMAIL:hyeyoon.park@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndCONFIRM:Y-
dc.identifier.rimsid42040-
dc.identifier.srndT201619561-
dc.type.rimsART-
Appears in Collections:
College of Natural Sciences (자연과학대학)Dept. of Physics and Astronomy (물리·천문학부)Physics (물리학전공)Journal Papers (저널논문_물리학전공)
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