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Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Bo-Ra | - |
dc.contributor.author | Kwon, Bo-Eun | - |
dc.contributor.author | Hong, Eun-Hye | - |
dc.contributor.author | Shim, Aeri | - |
dc.contributor.author | Song, Jae-Hyoung | - |
dc.contributor.author | Kim, Hong-Min | - |
dc.contributor.author | Chang, Sun-Young | - |
dc.contributor.author | Kim, Yeon-Jeong | - |
dc.contributor.author | Kweon, Mi-Na | - |
dc.contributor.author | Youn, Je-In | - |
dc.contributor.author | Ko, Hyun-Jeong | - |
dc.date.accessioned | 2017-04-19T00:45:52Z | - |
dc.date.available | 2017-11-28T10:58:22Z | - |
dc.date.created | 2018-09-07 | - |
dc.date.issued | 2016-10 | - |
dc.identifier.citation | Cancer Letters, Vol.381 No.1, pp.156-164 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | https://hdl.handle.net/10371/116933 | - |
dc.description.abstract | Interleukin-10 (IL-10) is a well-characterized anti-inflammatory cytokine, but its role in anti-cancer immunity is controversial. After injection with TC-1 cancer cells, we observed more rapid tumour growth and significantly higher interleukin-6 (IL-6) production in IL-10 knockout (IL-10(-/-)) mice than wild-type (WT) mice. Blocking IL-6 with an anti-IL-6 receptor (IL-6R) monoclonal antibody (mAb) inhibited tumour growth and myeloid-derived suppressor cell (MDSC) generation, which were significantly increased in IL-10-deficient mice. MDSCs and tumour cells from IL-10(-/-) mice had increased phosphorylated signal transducer and activator of transcription 3 (p-STAT3) levels. Treatment with a STAT3 inhibitor, S3I, reduced tumour growth, inhibited MDSC expansion, reduced IL-6 in tumours, and relieved T cell suppression. The combination of anti-IL-6R mAb and S3I further inhibited tumour growth compared to S3I treatment alone. These results suggested that the inhibition of the IL-6/STAT3 signalling axis is a candidate anti-cancer strategy, especially under systemic inflammatory conditions with high IL-6. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | Elsevier BV | - |
dc.title | Interleukin-10 attenuates tumour growth by inhibiting interleukin-6/signal transducer and activator of transcription 3 signalling in myeloid-derived suppressor cells | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 이보라 | - |
dc.contributor.AlternativeAuthor | 권보은 | - |
dc.contributor.AlternativeAuthor | 홍은혜 | - |
dc.contributor.AlternativeAuthor | 송재형 | - |
dc.contributor.AlternativeAuthor | 김홍민 | - |
dc.contributor.AlternativeAuthor | 장순영 | - |
dc.contributor.AlternativeAuthor | 김연정 | - |
dc.contributor.AlternativeAuthor | 권미나 | - |
dc.contributor.AlternativeAuthor | 연제인 | - |
dc.contributor.AlternativeAuthor | 고현정 | - |
dc.author.alternative | 심애리 | - |
dc.identifier.doi | 10.1016/j.canlet.2016.07.012 | - |
dc.citation.journaltitle | Cancer Letters | - |
dc.identifier.wosid | 000383935600019 | - |
dc.identifier.scopusid | 2-s2.0-84982850702 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201502279 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079617 | - |
dc.description.srnd | CITE_RATE:5.992 | - |
dc.description.srnd | DEPT_NM:의과학과 | - |
dc.description.srnd | EMAIL:jiyoun@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.description.srnd | CONFIRM:Y | - |
dc.citation.endpage | 164 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 156 | - |
dc.citation.volume | 381 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Youn, Je-In | - |
dc.identifier.srnd | T201502279 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | ANTIINFLAMMATORY RESPONSE | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | CANCER-RISK | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | STAT3 | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | MICROENVIRONMENT | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Interleukin-6 | - |
dc.subject.keywordAuthor | Myeloid-derived suppressor cells | - |
dc.subject.keywordAuthor | Interleukin-10 | - |
dc.subject.keywordAuthor | Signal transducer and activator of transcription 3 | - |
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