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Microtechnology-based organ systems and whole-body models for drug screening

Cited 15 time in Web of Science Cited 13 time in Scopus
Authors
Lee, Seung Hwan; Ha, Sang Keun; Choi, Nakwon; Park, Tai Hyun; Sung, Jong Hwan
Major
공과대학 화학생물공학부
Issue Date
2016-04-06
Publisher
Wiley-VCH Verlag GmbH & Co. KGaA
Citation
BIOTECHNOLOGY JOURNAL Vol.11, pp. 746-756
Keywords
In vitro systemsMicrofluidicsMicrotechnologyMultiple organ interactionOrgan-on-a-chip
Abstract
After drug administration, the drugs are absorbed, distributed, metabolized, and excreted (ADME). Because ADME processes affect drug efficacy, various in vitro models have been developed based on the ADME processes. Although these models have been widely accepted as a tool for predicting the effects of drugs, the differences between in vivo and in vitro systems result in high attrition rates of drugs during the development process and remain a major limitation. Recent advances in microtechnology enable more accurate mimicking of the in vivo environment, where cellular behavior and physiological responses to drugs are more realistic; this has led to the development of novel in vitro systems, known as “organ-on-a-chip” systems. The development of organ-on-a-chip systems has progressed to include the reproduction of multiple organ interactions, which is an important step towards “body-on-a-chip” systems that will ultimately predict whole-body responses to drugs. In this review, we summarize the application of microtechnology for the development of in vitro systems that accurately mimic in vivo environments and reconstruct multiple organ models.
ISSN
1860-6768
Language
English
URI
http://hdl.handle.net/10371/116992
DOI
https://doi.org/10.1002/biot.201500551
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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