Publications

Detailed Information

Duplex Bioelectronic Tongue for Sensing Umami and Sweet Tastes Based on Human Taste Receptor Nanovesicles

DC Field Value Language
dc.contributor.authorAhn, Sae Ryunen
dc.contributor.authorAn, Ji Hyun-
dc.contributor.authorSong, Hyun Seok-
dc.contributor.authorPark, Jin Wook-
dc.contributor.authorLee, Sang Hun-
dc.contributor.authorKim, Jae Hyun-
dc.contributor.authorJang, Jyongsik-
dc.contributor.authorPark, Tai Hyun-
dc.date.accessioned2017-04-21T02:30:03Z-
dc.date.available2017-05-11T16:42:47Z-
dc.date.issued2016-06-21-
dc.identifier.citationACS NANO Vol.10 No.8, pp. 7287-7296-
dc.identifier.issn1936-0851-
dc.identifier.urihttps://hdl.handle.net/10371/116993-
dc.description.abstractFor several decades, significant efforts have been made in developing artificial taste sensors to recognize the five basic tastes. So far, the well-established taste sensor is an E-tongue, which is constructed with polymer and lipid membranes. However, the previous artificial taste sensors have limitations in various food, beverage, and cosmetic industries because of their failure to mimic human taste reception. There are many interactions between tastants. Therefore, detecting the interactions in a multiplexing system is required. Herein, we developed a duplex bioelectronic tongue (DBT) based on graphene field-effect transistors that were functionalized with heterodimeric human umami taste and sweet taste receptor nanovesicles. Two types of nanovesicles, which have human T1R1/T1R3 for the umami taste and human T1R2/T1R3 for the sweet taste on their membranes, immobilized on micropatterned graphene surfaces were used for the simultaneous detection of the umami and sweet tastants. The DBT platform led to highly sensitive and selective recognition of target tastants at low concentrations (ca. 100 nM). Moreover, our DBT was able to detect the enhancing effect of taste enhancers as in a human taste sensory system. This technique can be a useful tool for the detection of tastes instead of sensory evaluation and development of new artificial tastants in the food and beverage industry.en
dc.language.isoenen
dc.publisherAmerican Chemical Societyen
dc.subjectG-protein coupled receptor (GPCR)en
dc.subjecttaste receptoren
dc.subjectnanovesicle-
dc.subjectbioelectronic tongue-
dc.subjectduplex taste sensor-
dc.subjectgraphene-
dc.subjectfield-effect transistor (FET)-
dc.titleDuplex Bioelectronic Tongue for Sensing Umami and Sweet Tastes Based on Human Taste Receptor Nanovesiclesen
dc.typeArticle-
dc.contributor.AlternativeAuthor안세련-
dc.contributor.AlternativeAuthor안지현-
dc.contributor.AlternativeAuthor송현석-
dc.contributor.AlternativeAuthor박진욱-
dc.contributor.AlternativeAuthor이상훈-
dc.contributor.AlternativeAuthor김재현-
dc.contributor.AlternativeAuthor장정식-
dc.contributor.AlternativeAuthor박태현-
dc.identifier.doi10.1021/acsnano.6b02547-
dc.description.srndOAIID:RECH_ACHV_DSTSH_NO:T201623718-
dc.description.srndRECH_ACHV_FG:RR00200001-
dc.description.srndADJUST_YN:-
dc.description.srndEMP_ID:A002014-
dc.description.srndCITE_RATE:13.334-
dc.description.srndFILENAME:5. (2016.08) Duplex Bioelectronic Tongue for Sensing.pdf-
dc.description.srndDEPT_NM:화학생물공학부-
dc.description.srndEMAIL:thpark@snu.ac.kr-
dc.description.srndSCOPUS_YN:Y-
dc.description.srndFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/a850a759-12d7-4f60-b7c9-754b59d9e733/link-
dc.description.srndCONFIRM:Y-
dc.identifier.srndT201623718-
Appears in Collections:
Files in This Item:
There are no files associated with this item.

Altmetrics

Item View & Download Count

  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Share