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A Promising Road in Colorectal Cancer Treatment: Personalized Immunotherapy Based on Molecular and Immune Classification System

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Authors
Oh, SeungJu Jackie; Lee, Wooin; Lockhart, A. Craig
Issue Date
2016-01
Publisher
AME PUBL CO
Citation
Translational Cancer Research, Vol.5 No.3, pp. 327-329
Keywords
A Promising Road in Colorectal Cancer Treatment: Personalized Immunotherapy Based on Molecular and Immune Classification System의약학
Abstract
Immunotherapy has increasingly proven to be a key treatment modality that can make a significant impact on the lives of many cancer patients. In particular, immune checkpoint inhibitors targeting the programmed cell death protein 1 (PD-1) pathway have led to remarkable clinical benefits in various cancers, including melanoma and lung cancer, and active investigations are ongoing to expand their therapeutic utility in other cancer types (1). In fact, several clinical trials have revealed a link between high somatic mutation prevalence and the clinical success in PD-1 axis blockade. Considering that colorectal cancers (CRC) are known to have very high rates of somatic mutations in comparison to other solid cancers (2), the potential of immunotherapeutic agents in treating patients with CRC is encouraging (3,4).
ISSN
2218-676X
Language
English
URI
http://hdl.handle.net/10371/117536
DOI
https://doi.org/10.21037/tcr.2016.06.30
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College of Pharmacy (약학대학)Research Institute of Pharmaceutical Sciences (종합약학연구소)Journal Papers (저널논문_종합약학연구소)
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