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Diabetic retinopathy is associated with diastolic dysfunction in type 2 diabetic patients with non-ischemic dilated cardiomyopathy
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Yoo-Ri | - |
dc.contributor.author | Park, Se-Jun | - |
dc.contributor.author | Moon, Ka Young | - |
dc.contributor.author | Choi, Seoyoung Annie | - |
dc.contributor.author | Lim, Hong-Seok | - |
dc.contributor.author | Park, Sung Wook | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Lee, Kihwang | - |
dc.date.accessioned | 2017-07-10T06:40:14Z | - |
dc.date.available | 2017-07-19T11:27:20Z | - |
dc.date.issued | 2017-07-06 | - |
dc.identifier.citation | Cardiovascular Diabetology, 16(1):82 | ko_KR |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | 10.1186/s12933-017-0566-y | - |
dc.identifier.uri | https://hdl.handle.net/10371/117777 | - |
dc.description.abstract | Background
To investigate the association between diabetic retinopathy (DR) and myocardial dysfunction in patients with type 2 diabetes and dilated cardiomyopathy (dCMP). Methods Data were collected retrospectively from 89 patients with dCMP (46 with type 2 diabetes and 43 without diabetes) and no evidence of coronary artery disease. Echocardiographic parameters and laboratory data, including lipid profiles and fundus findings, were obtained from medical records. A left ventricular ejection fraction (LVEF) less than 40% was considered impaired systolic function, while an E/E′ ratio greater than 15 was considered elevated left ventricular (LV) filling pressure. Results Baseline characteristics show that LVEF was not significantly different between patients with and without diabetes or between diabetic patients with and without DR. Among the diastolic function parameters, patients with DR exhibited higher E/E′ ratios (left ventricular filling pressures) than patients without DR (23.75±13.37 vs 11.71±3.50, P=0.022). Logistic regression analysis revealed that statin use lowered the risk of impaired systolic dysfunction in all patients (odds ratio (OR) 0.33, 95% confidence interval (CI) 0.12–0.92, P=0.034) and in patients with diabetes (OR 0.273, 95% CI 0.08–0.99, P=0.049), while the presence of DR was associated with a higher risk of elevated LV filling filling pressure in patients with diabetes (OR 18.00, 95% CI 1.50–216.62, P=0.023). Conclusions In conclusion, DR was associated with elevated LV filling pressure in patients with dCMP. DR may not only represent microvascular long-term complications in patients with diabetes but may also be associated with more advanced form of diastolic dysfunction among diabetic patients with cardiomyopathy. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BioMed Central | ko_KR |
dc.subject | Cardiomyopathy | ko_KR |
dc.subject | Diabetic retinopathy | ko_KR |
dc.subject | Diastolic dysfunction | ko_KR |
dc.subject | Microcirculation | ko_KR |
dc.title | Diabetic retinopathy is associated with diastolic dysfunction in type 2 diabetic patients with non-ischemic dilated cardiomyopathy | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 정유리 | - |
dc.contributor.AlternativeAuthor | 박세준 | - |
dc.contributor.AlternativeAuthor | 문가영 | - |
dc.contributor.AlternativeAuthor | 최서영 | - |
dc.contributor.AlternativeAuthor | 임홍석 | - |
dc.contributor.AlternativeAuthor | 박성욱 | - |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 이기황 | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2017-07-09T03:22:47Z | - |
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