Effect of subconjunctivally injected, liposome-bound, low-molecular-weight heparin on the absorption rate of subconjunctival hemorrhage in rabbits

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Moon, Jun-Woong; Song, Yun-Kyoung; Jee, Jun-Pil; Kim, Chong-Kook; Choung, Ho-Kyung; Hwang, Jeong-Min
Issue Date
Association for Research in Vision and Ophthalmology
Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3968-74.
AbsorptionAnimalsConjunctiva/blood supply/drug effectsConjunctival Diseases/drug therapy/metabolism/*physiopathologyDisease Models, AnimalDrug CarriersEye Hemorrhage/drug therapy/metabolism/*physiopathologyFibrinolytic Agents/*administration & dosage/adverse effectsHeparin, Low-Molecular-Weight/*administration & dosage/adverse effectsInjectionsLiposomesRabbitsTime Factors
PURPOSE: To investigate the effect of subconjunctival injection of liposome-bound, low-molecular-weight heparin (LMWH) on the absorption rate of subconjunctival hemorrhages. METHODS: Subconjunctival hemorrhages were induced in both eyes of 30 rabbits by the subconjunctival injection of 0.1 mL of autologous blood from auricular marginal veins. After 8 hours, randomized subconjunctival injections of one of three materials were made: 5 IU/mL liposome-bound LMWH (0.1 mL) in 18 eyes (group A), only liposomes (0.1 mL) in 14 eyes (group B), the free form of LMWH (5 IU/mL, 0.1 mL) in 14 eyes (group C), or no injection in 14 eyes (group D). Subconjunctival hemorrhages were photographed with a digital camera at 8, 24, 48, 72, 96, and 120 hours after induction of subconjunctival hemorrhages, sized with an image analyzer, and compared between groups. RESULTS: Subconjunctival hemorrhages were absorbed faster in group A (liposome-bound LMWH injected) than in with group B (liposome injected). Comparison of groups A and C (free LMWH injected) showed statistical differences in the absorption rates at 96 and 120 hours except at 24, 48, and 72 hours. The mean elapsed time for the complete resorption of subconjunctival hemorrhages was shortest in group A among four groups, whereas group B and the control showed no significant differences. The ocular and systemic absorption of LMWH were significantly lower after injection of the liposome-bound than the free form. CONCLUSIONS: The subconjunctival injection of liposome-bound LMWH appears to enhance subconjunctival hemorrhage absorption in rabbits.
0146-0404 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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