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Capillarity Guided Patterning of Microliquids : 모세관 현상을 이용한 미소 액체 패터닝 기법
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- Authors
- Advisor
- 전누리
- Major
- 공과대학 기계항공공학부(멀티스케일 기계설계전공)
- Issue Date
- 2015-08
- Publisher
- 서울대학교 대학원
- Keywords
- Lab-on-a-chip ; Liquid patterning ; Microfluidics ; Surface tension ; High-throughput screening ; Organ-on-a-chip
- Description
- 학위논문 (박사)-- 서울대학교 대학원 : 기계항공공학부 멀티스케일 기계설계전공, 2015. 8. 전누리.
- Abstract
- Soft lithography and other techniques have been developed to investigate biological and chemical phenomena as an alternative to photolithography-based patterning methods that have compatibility problems. This paper describes a simple and novel approach for non-lithographic patterning of liquids and gels. Using a design that incorporates strategically placed microstructures, micro-liquids or gels can be spontaneously trapped and patterned using the surface tension between liquid and microstructures. The main advantage of this method is simplicity. Various liquid patterns with ~1nL were patterned by simple liquid draining or wiping motion. This method is geometrically analyzed based on hydrodynamics and verified with simulation and experiments. Various materials (i.e. water, hydrogels and other liquids) have been successfully patterned with complex shapes that are isolated from each other. Multiple cell types are patterned within the gels. Capillarity guided patterning is fast, simple and robust. It is not limited by pattern shape, size, cell type and material. The simplicity and robustness of the capillarity guided patterning will be attractive in developing novel in-vitro models of organ-on-a-chip, high-throughput screening and other biological experimental platforms amenable to long-term observation of dynamic events using advanced imaging and analytical techniques.
- Language
- English
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