Publications
Detailed Information
Diagnostic role of anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic antibodies in patients with inflammatory bowel disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Byeong Gwan | - |
dc.contributor.author | Kim, You Sun | - |
dc.contributor.author | Kim, Joo Sung | - |
dc.contributor.author | Jung, Hyun Chae | - |
dc.contributor.author | Song, In Sung | - |
dc.date.accessioned | 2009-11-10T14:15:18Z | - |
dc.date.available | 2009-11-10T14:15:18Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Dis Colon Rectum 2002;45:1062-9 | en |
dc.identifier.issn | 0012-3706 (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12195191 | - |
dc.identifier.uri | https://hdl.handle.net/10371/11865 | - |
dc.description.abstract | PURPOSE: Perinuclear antineutrophil cytoplasmic autoantibody is known to be a marker for ulcerative colitis, and anti-Saccharomyces cerevisiae Mannan antibody is a serologic marker associated with Crohn's disease. The aim of this study was to assess the value of detecting perinuclear antineutrophil cytoplasmic autoantibody and/or anti-Saccharomyces cerevisiae Mannan antibody for the diagnosis of ulcerative colitis, Crohn's disease, Behcet's colitis, and tuberculous colitis. METHODS: Serum samples were obtained from 85 patients with Crohn's disease, 77 with ulcerative colitis, 36 with Behcet's colitis, 14 with tuberculous colitis, 20 healthy controls, and 21 first-degree relatives of patients with Crohn's disease. Determination of perinuclear antineutrophil cytoplasmic autoantibody and anti-Saccharomyces cerevisiae Mannan antibody was performed with the standardized indirect immunofluorescence technique and an enzyme-linked immunosorbent assay, respectively. RESULTS: A relatively high percentage of patients with Crohn's disease (49.4 percent), relatives of Crohn's disease patients (61.9 percent), and patients with Behcet's disease (41.7 percent) tested seropositive for anti-Saccharomyces cerevisiae Mannan antibody compared with normal controls (10 percent). In cases of ulcerative colitis, 44.2 percent tested seropositive for perinuclear antineutrophil cytoplasmic autoantibody, whereas the controls showed 0 percent positivity. The combination of a positive anti-Saccharomyces cerevisiae Mannan antibody test and a negative perinuclear antineutrophil cytoplasmic autoantibody yielded a sensitivity and specificity of 48.2 and 87 percent, respectively, for Crohn's disease. The combination of a positive perinuclear antineutrophil cytoplasmic autoantibody test and a negative anti-Saccharomyces cerevisiae Mannan antibody test yielded a sensitivity and specificity of 36.4 and 97.6 percent, respectively, for ulcerative colitis. CONCLUSION: Anti-Saccharomyces cerevisiae Mannan antibody may be associated with Crohn's disease and Behcet's disease and perinuclear antineutrophil cytoplasmic autoantibody with ulcerative colitis. A combination of both tests may aid the differential diagnosis of inflammatory bowel disease. | en |
dc.description.sponsorship | Supported by a grant from SK Pharma Research Fund of the Korean
Society of Gastroenterology. | en |
dc.language.iso | en | - |
dc.publisher | Springer Verlag | en |
dc.subject | Antibodies, Antineutrophil Cytoplasmic/blood/*immunology | en |
dc.subject | Antibodies, Fungal/blood/*immunology | en |
dc.subject | Biological Markers/blood | en |
dc.subject | Chi-Square Distribution | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Fluorescent Antibody Technique, Indirect | en |
dc.subject | Inflammatory Bowel Diseases/blood/*diagnosis/*immunology | en |
dc.subject | Prospective Studies | en |
dc.subject | Saccharomyces cerevisiae/*immunology | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Statistics, Nonparametric | en |
dc.title | Diagnostic role of anti-Saccharomyces cerevisiae mannan antibodies combined with antineutrophil cytoplasmic antibodies in patients with inflammatory bowel disease | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 김병관 | - |
dc.contributor.AlternativeAuthor | 김유선 | - |
dc.contributor.AlternativeAuthor | 김주성 | - |
dc.contributor.AlternativeAuthor | 정현채 | - |
dc.contributor.AlternativeAuthor | 송인성 | - |
dc.identifier.doi | 10.1007/s10350-004-6361-3 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.