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Conserved extended haplotypes of the major histocompatibility complex: further characterization

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dc.contributor.authorDorak, M T-
dc.contributor.authorShao, W-
dc.contributor.authorMachulla, H K G-
dc.contributor.authorLobashevsky, E S-
dc.contributor.authorTang, J-
dc.contributor.authorPark, M H-
dc.contributor.authorKaslow, R A-
dc.date.accessioned2009-11-10T14:37:44Z-
dc.date.available2009-11-10T14:37:44Z-
dc.date.issued2006-
dc.identifier.citationGenes Immun 2006; 7: 450-467en
dc.identifier.issn1466-4879 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16791278-
dc.identifier.urihttps://hdl.handle.net/10371/11869-
dc.description.abstractSince the complete sequencing of a human major histocompatibility complex (MHC) haplotype, interest in non-human leucocyte antigen (HLA) genes encoded in the MHC has been growing. Non-HLA genes, which outnumber the HLA genes, may contribute to or account for HLA and disease associations. Most information on non-HLA genes has been obtained in separate studies of individual loci. To comprehensively address polymorphisms of relevant non-HLA genes in 'conserved extended haplotypes' (CEH), we investigated 101 International Histocompatibility Workshop reference cell lines and nine additional anonymous samples representing all 37 unambiguously characterized CEHs at MICA, NFKBIL1, LTA, NCR3, AIF1, HSPA1A, HSPA1B, BF, NOTCH4 and a single nucleotide polymorphism (SNP) at HLA-DQA1 as well as MICA, NOTCH4, HSPA1B and all five tumour necrosis factor short tandem repeat (STR) polymorphisms. This work (1) provides an extensive catalogue of MHC polymorphisms in all CEHs, (2) unravels interrelationships between HLA and non-HLA haplotypical lineages, (3) resolves reported typing ambiguities and (4) describes haplospecific markers for a number of CEHs. Analysis also identified a DQA1 SNP and segments containing MHC class III polymorphisms that corresponded with class II (DRB3 and DRB4) lineages. These results portray the MHC where lineages containing non-HLA and HLA variants in linkage disequilibrium may operate in concert and can guide more thorough design and interpretation of HLA-disease relationships.en
dc.language.isoenen
dc.publisherNature Publishing Groupen
dc.subject3' Untranslated Regionsen
dc.subjectCell Lineen
dc.subjectDNA-Binding Proteins/geneticsen
dc.subjectHLA-B Antigens/geneticsen
dc.subjectHLA-DQ Antigens/geneticsen
dc.subjectHSP70 Heat-Shock Proteins/geneticsen
dc.subjectHistocompatibility Antigens Class I/geneticsen
dc.subjectHistocompatibility Antigens Class II/geneticsen
dc.subjectLymphotoxin-alpha/geneticsen
dc.subjectMajor Histocompatibility Complex/*geneticsen
dc.subjectNatural Cytotoxicity Triggering Receptor 3en
dc.subjectPolymorphism, Single Nucleotideen
dc.subjectProto-Oncogene Proteins/geneticsen
dc.subjectReceptors, Immunologic/geneticsen
dc.subjectReceptors, Notch/geneticsen
dc.subjectTandem Repeat Sequencesen
dc.subjectTumor Necrosis Factor-alpha/geneticsen
dc.subjectHaplotypes-
dc.subjectPolymorphism, Genetic-
dc.titleConserved extended haplotypes of the major histocompatibility complex: further characterizationen
dc.typeArticleen
dc.identifier.doi10.1038/sj.gene.6364315-
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