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Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies

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Authors
Kim, Inho; Yoon, Sung Soo; Lee, Kyung-Hun; Keam, Bhumsuk; Kim, Tae Min; Kim, Jin-Soo; Kim, Hoon-Gu; Oh, Myoung-Don; Han, Kyou-Sup; Park, Myoung Hee; Park, Seonyang; Kim, Byoung Kook
Issue Date
2006-07-18
Publisher
Blackwell Publishing
Citation
Clin Transplant. 2006 Jul-Aug;20(4):496-503.
Keywords
AdultAntineoplastic Combined Chemotherapy Protocols/therapeutic useFemaleGraft vs Host DiseaseHematologic Neoplasms/mortality/*therapyHematopoietic Stem Cell Transplantation/*methodsHistocompatibility TestingHumansMaleMelphalan/administration & dosageMiddle AgedSurvival AnalysisTransplantation ConditioningTransplantation, Homologous/*physiologyTreatment Outcome
Abstract
We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies<50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)-matched donors, via either reduced intensity (n=35) or myeloablative conditioning (n=70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p=0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count>0.5x10(9)/L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0-21 d) than in the myeloablative group (median: 18 d; range: 11-38 d; p<0.0001). The incidence of grades 2-4 acute graft-vs.-host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p=0.40). The cumulative incidence of day 100 non-relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p=0.88). The overall two-yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p=0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies.
ISSN
0902-0063 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16842528

http://hdl.handle.net/10371/11878
DOI
https://doi.org/10.1111/j.1399-0012.2006.00512.x
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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