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Comparative outcomes of reduced intensity and myeloablative allogeneic hematopoietic stem cell transplantation in patients under 50 with hematologic malignancies
Cited 2 time in
Web of Science
Cited 2 time in Scopus
- Authors
- Issue Date
- 2006-07-18
- Publisher
- Blackwell Publishing
- Citation
- Clin Transplant. 2006 Jul-Aug;20(4):496-503.
- Keywords
- Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Graft vs Host Disease ; Hematologic Neoplasms/mortality/*therapy ; Hematopoietic Stem Cell Transplantation/*methods ; Histocompatibility Testing ; Humans ; Male ; Melphalan/administration & dosage ; Middle Aged ; Survival Analysis ; Transplantation Conditioning ; Transplantation, Homologous/*physiology ; Treatment Outcome
- Abstract
- We have conducted a direct comparison of the outcomes of reduced intensity and myeloablative conditioning in younger adults with hematological malignancies<50 yr. One hundred and five patients received transplants from human leukocyte antigen (HLA)-matched donors, via either reduced intensity (n=35) or myeloablative conditioning (n=70). The median ages of the reduced intensity and myeloablative groups were 36 and 33 yr (p=0.014). Neutrophil engraftment (i.e. time to absolute neutrophil count>0.5x10(9)/L) occurred more rapidly in the reduced intensity group (median: 10 d; range: 0-21 d) than in the myeloablative group (median: 18 d; range: 11-38 d; p<0.0001). The incidence of grades 2-4 acute graft-vs.-host disease were similar between the reduced intensity and myeloablative groups, at 17% vs. 24% respectively (p=0.40). The cumulative incidence of day 100 non-relapse mortality was 18% in the reduced intensity group, and 21% in the myeloablative group (p=0.88). The overall two-yr survival rates were 43% in the reduced intensity group, and 35% in the myeloablative group (p=0.72). In conclusion, reduced intensity transplantation yielded outcomes comparable with those of myeloablative transplantation in patients under 50 with hematological malignancies.
- ISSN
- 0902-0063 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16842528
https://hdl.handle.net/10371/11878
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