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Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage

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dc.contributor.authorLee, Soon-Tae-
dc.contributor.authorChu, Kon-
dc.contributor.authorSinn, Dong-In-
dc.contributor.authorJung, Keun-Hwa-
dc.contributor.authorKim, Eun-Hee-
dc.contributor.authorKim, Se-Jeong-
dc.contributor.authorKim, Jeong-Min-
dc.contributor.authorKo, Song-Yi-
dc.contributor.authorKim, Manho-
dc.contributor.authorRoh, Jae-Kyu-
dc.date.accessioned2009-11-11T03:08:37Z-
dc.date.available2009-11-11T03:08:37Z-
dc.date.issued2006-03-17-
dc.identifier.citationJ Neurochem. 2006 Mar;96(6):1728-39.en
dc.identifier.issn0022-3042 (Print)-
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16539688-
dc.identifier.urihttps://hdl.handle.net/10371/11879-
dc.description.abstractErythropoietin (EPO), a pleiotropic cytokine involved in erythropoiesis, is tissue-protective in ischemic, traumatic, toxic and inflammatory injuries. In this study, we investigated the effect of EPO in experimental intracerebral hemorrhage (ICH). Two hours after inducing ICH via the stereotaxic infusion of collagenase, recombinant human EPO (500 or 5000 IU/kg, ICH + EPO group) or PBS (ICH + vehicle group) was administered intraperitoneally, then once daily afterwards for 1 or 3 days. ICH + EPO showed the better functional recovery in both rotarod and modified limb placing tests. The brain water content was decreased in ICH + EPO dose-dependently, as compared with ICH + vehicle. The effect of EPO on the brain water content was inhibited by N(omega)-Nitro-L-arginine methyl ester hydrochloride (L-NAME, 10 mg/kg). Mean hemorrhage volume was also decreased in ICH + EPO. EPO reduced the numbers of TUNEL +, myeloperoxidase + or OX-42 + cells in the perihematomal area. In addition, EPO reduced the mRNA level of TNF-alpha, Fas and Fas-L, as well as the activities of caspase-8, 9 and 3. EPO treatment showed up-regulations of endothelial nitric oxide synthase (eNOS) and p-eNOS, pAkt, pSTAT3 and pERK levels. These data suggests that EPO treatment in ICH induces better functional recovery with reducing perihematomal inflammation and apoptosis, coupled with activations of eNOS, STAT3 and ERK.en
dc.language.isoen-
dc.publisherBlackwell Publishingen
dc.subjectAnimalsen
dc.subjectApoptosis/drug effects/physiologyen
dc.subjectBiological Markers/metabolismen
dc.subjectBody Water/drug effects/physiologyen
dc.subjectBrain/drug effects/metabolism/physiopathologyen
dc.subjectBrain Edema/drug therapy/etiology/physiopathologyen
dc.subjectCell Death/drug effects/physiologyen
dc.subjectCerebral Hemorrhage/complications/*drug therapy/physiopathologyen
dc.subjectDisease Models, Animalen
dc.subjectDose-Response Relationship, Drugen
dc.subjectEncephalitis/*drug therapy/etiology/physiopathologyen
dc.subjectEnzyme Activation/drug effects/physiologyen
dc.subjectEnzyme Inhibitors/pharmacologyen
dc.subjectErythropoietin/*pharmacology/therapeutic useen
dc.subjectMaleen
dc.subjectNG-Nitroarginine Methyl Ester/pharmacologyen
dc.subjectNerve Degeneration/*drug therapy/etiology/physiopathologyen
dc.subjectNitric Oxide Synthase Type III/*drug effects/metabolismen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectRecovery of Function/drug effects/physiologyen
dc.subjectSTAT3 Transcription Factor/*drug effects/metabolismen
dc.subjectSignal Transduction/drug effects/physiologyen
dc.subjectTreatment Outcomeen
dc.titleErythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhageen
dc.typeArticleen
dc.contributor.AlternativeAuthor이순태-
dc.contributor.AlternativeAuthor주건-
dc.contributor.AlternativeAuthor신동인-
dc.contributor.AlternativeAuthor정근화-
dc.contributor.AlternativeAuthor김은희-
dc.contributor.AlternativeAuthor김세정-
dc.contributor.AlternativeAuthor김정민-
dc.contributor.AlternativeAuthor고송이-
dc.contributor.AlternativeAuthor김만호-
dc.contributor.AlternativeAuthor노재규-
dc.identifier.doi10.1111/j.1471-4159.2006.03697.x-
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