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유중수 (w/o)형 마이크로에멀젼을 이용한 독소루비신의 경구 전달
Water-in-oil (w/o) Microemulsion for Oral Delivery of Doxorubicin

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Authors
김지언
Advisor
김대덕
Major
약학대학 제약학과
Issue Date
2014-02
Publisher
서울대학교 대학원
Keywords
doxorubicinoral deliveryparacellular pathwaymedium chain glyceridemicroemulsion
Description
학위논문 (박사)-- 서울대학교 대학원 : 제약학과, 2014. 2. 김대덕.
Abstract
Purpose: Although doxorubicin (DOX) is a potent anticancer drug, development of its oral formulation has been hindered by its limited intestinal absorption and low oral bioavailability. The limited intestinal absorption via the paracellular pathway may be the primary cause of the low oral bioavailability of DOX. In this study, medium chain glycerides-based colloidal systems were formulated to enhance the intestinal paracellular absorption of DOX thereby improving its oral delivery.
Methods: The DOX formulations prepared by the construction of pseudo-ternary phase diagram were characterized in terms of their droplet size distribution, viscosity, drug loading and drug release. Further evaluation was conducted by an in vitro Caco-2 cell transport study as well as in situ / in vivo intestinal absorption, bioavailability and toxicity studies.
Results: The water-in-oil (w/o) microemulsion systems consisting of Captex 355 (oil), Span 80/ Tween 80 or Capmul MCM/Labrasol (surfactant mixture) and water were developed for oral delivery of DOX. Compared with DOX solution, these formulations enhanced the absorptive transport of DOX across Caco-2 cell monolayers at least partly due to the paracellular-enhancing effects of their lipidic components. Moreover, the in situ intestinal absorption and in vivo oral bioavailability of DOX in rats were markedly enhanced. In addition, no discernible damage was observed in the rat jejunum after oral administration of these DOX formulations while the cardiac toxicity was significantly reduced when compared with intravenous DOX solution.
Conclusions: The medium chain glycerides-based colloidal system prepared in this study represents a potentially effective oral delivery system for DOX.
Language
Korean
URI
http://hdl.handle.net/10371/120024
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College of Pharmacy (약학대학)Dept. of Manufacturing Pharmacy (제약학과)Theses (Ph.D. / Sc.D._제약학과)
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