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Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Roh, Eun Youn | - |
dc.contributor.author | Park, Myoung Hee | - |
dc.contributor.author | Park, Hyejin | - |
dc.contributor.author | Park, Doo-Heum | - |
dc.contributor.author | Choi, Jong-Bae | - |
dc.contributor.author | Kim, Seog Ju | - |
dc.contributor.author | Jeong, Do-Un | - |
dc.date.accessioned | 2009-11-13T04:11:14Z | - |
dc.date.available | 2009-11-13T04:11:14Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | Hum Immunol 67:749 | en |
dc.identifier.issn | 0198-8859 (Print) | - |
dc.identifier.issn | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17002906 | - |
dc.identifier.uri | https://hdl.handle.net/10371/12118 | - |
dc.description.abstract | The purpose of this study was to investigate the association of human leukocyte antigen (HLA) class II alleles with narcolepsy-cataplexy susceptibility in Koreans. The distribution of HLA-DRB1 and -DQB1 alleles and presence or absence of DRB3/4/5 alleles were examined in 60 narcoleptic patients with clear-cut cataplexy, and the results were compared with two groups of healthy controls: 200 randomly selected controls and 144 DRB1*1501-DQB1*0602 positive controls. All of the narcoleptic patients were DRB1*1501 and DQB1*0602 positive, and their frequencies were significantly higher in patients than in random controls (100% vs 17.0%, p(c) = 2.3 x 10(-30), OR = 583.96; 100% vs 16.5%, p(c) = 3.9 x 10(-31), OR = 605.00). The HLA association in Koreans was as tight as that reported in Japanese. Several DRB1 (*0101, *0405, *0901) and DQB1 alleles (*0303, *0401, *0501, *0601, *0604) were found to have weak protective effects against narcolepsy. DRB4 showed strong protective effect, and this was also significant when compared with DRB1*1501-DQB1*0602 positive controls (18.3% vs 44.4%, p(c) = 0.001, OR = 0.28). DRB3 (OR = 1.86) and DQB1*0301 (OR = 2.45) were found to have weak predisposing effect, when compared with DRB1*1501-DQB1*0602 positive controls. The protective effect of DRB4 has to be further studied in other populations. | en |
dc.description.sponsorship | This work was supported by the Seoul National University
Research fund (800-20010242). | en |
dc.language.iso | en | - |
dc.publisher | Elsevier | en |
dc.subject | Cataplexy/*genetics | en |
dc.subject | Gene Frequency | en |
dc.subject | HLA-DQ Antigens/*genetics | en |
dc.subject | HLA-DR Antigens/*genetics | en |
dc.subject | Korea/epidemiology | en |
dc.subject | Narcolepsy/*genetics | en |
dc.subject | Phenotype | en |
dc.subject | Polymerase Chain Reaction | en |
dc.subject | Genetic Predisposition to Disease | - |
dc.title | Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 노은연 | - |
dc.contributor.AlternativeAuthor | 박명희 | - |
dc.contributor.AlternativeAuthor | 박혜진 | - |
dc.contributor.AlternativeAuthor | 박두흠 | - |
dc.contributor.AlternativeAuthor | 최종배 | - |
dc.contributor.AlternativeAuthor | 김석주 | - |
dc.contributor.AlternativeAuthor | 정도언 | - |
dc.identifier.doi | 10.1016/j.humimm.2006.03.024 | - |
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