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Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjects

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dc.contributor.authorRoh, Eun Youn-
dc.contributor.authorPark, Myoung Hee-
dc.contributor.authorPark, Hyejin-
dc.contributor.authorPark, Doo-Heum-
dc.contributor.authorChoi, Jong-Bae-
dc.contributor.authorKim, Seog Ju-
dc.contributor.authorJeong, Do-Un-
dc.date.accessioned2009-11-13T04:11:14Z-
dc.date.available2009-11-13T04:11:14Z-
dc.date.issued2006-
dc.identifier.citationHum Immunol 67:749en
dc.identifier.issn0198-8859 (Print)-
dc.identifier.issnhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17002906-
dc.identifier.urihttps://hdl.handle.net/10371/12118-
dc.description.abstractThe purpose of this study was to investigate the association of human leukocyte antigen (HLA) class II alleles with narcolepsy-cataplexy susceptibility in Koreans. The distribution of HLA-DRB1 and -DQB1 alleles and presence or absence of DRB3/4/5 alleles were examined in 60 narcoleptic patients with clear-cut cataplexy, and the results were compared with two groups of healthy controls: 200 randomly selected controls and 144 DRB1*1501-DQB1*0602 positive controls. All of the narcoleptic patients were DRB1*1501 and DQB1*0602 positive, and their frequencies were significantly higher in patients than in random controls (100% vs 17.0%, p(c) = 2.3 x 10(-30), OR = 583.96; 100% vs 16.5%, p(c) = 3.9 x 10(-31), OR = 605.00). The HLA association in Koreans was as tight as that reported in Japanese. Several DRB1 (*0101, *0405, *0901) and DQB1 alleles (*0303, *0401, *0501, *0601, *0604) were found to have weak protective effects against narcolepsy. DRB4 showed strong protective effect, and this was also significant when compared with DRB1*1501-DQB1*0602 positive controls (18.3% vs 44.4%, p(c) = 0.001, OR = 0.28). DRB3 (OR = 1.86) and DQB1*0301 (OR = 2.45) were found to have weak predisposing effect, when compared with DRB1*1501-DQB1*0602 positive controls. The protective effect of DRB4 has to be further studied in other populations.en
dc.description.sponsorshipThis work was supported by the Seoul National University
Research fund (800-20010242).
en
dc.language.isoen-
dc.publisherElsevieren
dc.subjectCataplexy/*geneticsen
dc.subjectGene Frequencyen
dc.subjectHLA-DQ Antigens/*geneticsen
dc.subjectHLA-DR Antigens/*geneticsen
dc.subjectKorea/epidemiologyen
dc.subjectNarcolepsy/*geneticsen
dc.subjectPhenotypeen
dc.subjectPolymerase Chain Reactionen
dc.subjectGenetic Predisposition to Disease-
dc.titleAssociation of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB1*1501-DQB1*0602--positive subjectsen
dc.typeArticleen
dc.contributor.AlternativeAuthor노은연-
dc.contributor.AlternativeAuthor박명희-
dc.contributor.AlternativeAuthor박혜진-
dc.contributor.AlternativeAuthor박두흠-
dc.contributor.AlternativeAuthor최종배-
dc.contributor.AlternativeAuthor김석주-
dc.contributor.AlternativeAuthor정도언-
dc.identifier.doi10.1016/j.humimm.2006.03.024-
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