Isolated tumor cells in lymph nodes are not a prognostic marker for patients with stage I and stage II colorectal cancer

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Lee, Min Ro; Hong, Chang Won; Yoon, Sang Nam; Lim, Seok-Byung; Park, Kyu Joo; Lee, Min Jin; Kim, Woo Ho; Park, Jae-Gahb
Issue Date
John Wiley & Sons
J Surg Oncol 2006;93:13-18
Carcinoembryonic Antigen/bloodColorectal Neoplasms/mortality/*pathology/surgeryDisease-Free SurvivalImmunohistochemistryLymph Nodes/*pathologyLymphatic MetastasisNeoplasm InvasivenessNeoplasm StagingPrognosisRecurrence*Tumor Markers, Biological/blood
BACKGROUND AND OBJECTIVES: Lymph node metastasis is an important prognostic factor for colorectal cancer (CRC). The relationship between isolated tumor cells (ITC) in lymph nodes and the prognosis is controversial. The aim of this study is to evaluate the prognostic importance of ITC in lymph nodes from patients with stage I and II CRC. METHODS: We examined all the lymph nodes obtained during surgery from 121 consecutive patients with stage I and II CRC after a curative resection in 1999 by using monoclonal antibody against cytokeratin (MNF116). Clinicopathologic data and follow-up information were obtained from all patients. The mean follow up duration was 57 months. RESULTS: ITC were found in 50% (60/121) of the patients. The mean number of examined lymph node was 19.3 +/- 9.4. The presence of ITC was not related to clinicopathologic factors such as age, sex, location of tumor, tumor size, tumor depth, differentiation, lymphovascular invasion, and the preoperative CEA level, except for the tumor gross type (P = 0.002). There were no statistically significant differences for the recurrence rate (10/60 = 16.7% and 9/61 = 14.8%, respectively), and disease-free survival (P = 0.809) between the ITC positive group and ITC negative group. CONCLUSIONS: The presence of ITC detected by immunohistochemical staining does not have an influence on the prognosis of patients with stage I and II CRC.
0022-4790 (Print)
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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