Publications
Detailed Information
H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Mi Hee | - |
dc.contributor.author | Rhie, Gi-eun | - |
dc.contributor.author | Kim, Yeon Kyung | - |
dc.contributor.author | Park, Chi-Hyun | - |
dc.contributor.author | Cho, Kwang Hyun | - |
dc.contributor.author | Kim, Kyu Han | - |
dc.contributor.author | Eun, Hee Chul | - |
dc.contributor.author | Chung, Jin Ho | - |
dc.date.accessioned | 2009-11-17T23:50:13Z | - |
dc.date.available | 2009-11-17T23:50:13Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | J Invest Dermatol 125:221-229 | en |
dc.identifier.issn | 0022-202X (Print) | - |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16098030 | - |
dc.identifier.uri | https://hdl.handle.net/10371/12602 | - |
dc.description.abstract | To understand the molecular alterations occurring during the aging process, we compared mitogen-activated protein (MAP) kinase activities in the intrinsically aged and photoaged skins in the same individuals. Furthermore, we investigated the molecular events related to MAP kinase changes in intrinsically aged and photoaged skins. We found that extracellular-signal-regulated kinase (ERK) activity in photoaged skin was reduced, and that the activities of c-Jun N-terminal kinase (JNK) and p38 kinase were increased compared with intrinsically aged skin in the same individuals. Phospho-c-Jun levels and activator protein 1 activities in photoaged skin were also higher than in intrinsically aged skin. Moreover, catalase activity was found to be much reduced in primary dermal fibroblasts from photoaged skin, and as a result, H2O2 accumulated more in primary dermal fibroblasts in photoaged skin. In addition, treating primary dermal fibroblasts from photoaged skin with catalase reduced H2O2 levels, reversed aging-dependent MAP kinase changes, and inhibited matrix metalloproteinase (MMP)-1 expression. Our results indicate that the accumulation of reactive oxygen species due to catalase attenuation may be a critical aspect of the MAP kinase signaling changes that may lead to skin aging and photoaging in human skin in vivo. Thus, the induction and regulation of endogenous antioxidant enzymes including catalase may offer a strategy for preventing and treating skin aging. | en |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | en |
dc.subject | Catalase/*metabolism/pharmacology | en |
dc.subject | Cells, Cultured | en |
dc.subject | Dermis/cytology/*enzymology | en |
dc.subject | Extracellular Signal-Regulated MAP Kinases/metabolism | en |
dc.subject | Fibroblasts/cytology/enzymology | en |
dc.subject | Hydrogen Peroxide/*metabolism | en |
dc.subject | JNK Mitogen-Activated Protein Kinases/metabolism | en |
dc.subject | MAP Kinase Signaling System/drug effects/*physiology | en |
dc.subject | Matrix Metalloproteinase 1/metabolism | en |
dc.subject | Proto-Oncogene Proteins c-jun/metabolism | en |
dc.subject | Skin Aging/*physiology | en |
dc.subject | Transcription Factor AP-1/metabolism | en |
dc.subject | Up-Regulation/physiology | en |
dc.subject | p38 Mitogen-Activated Protein Kinases/metabolism | en |
dc.title | H2O2 accumulation by catalase reduction changes MAP kinase signaling in aged human skin in vivo | en |
dc.type | Article | en |
dc.contributor.AlternativeAuthor | 신미희 | - |
dc.contributor.AlternativeAuthor | 이지은 | - |
dc.contributor.AlternativeAuthor | 김연경 | - |
dc.contributor.AlternativeAuthor | 박지현 | - |
dc.contributor.AlternativeAuthor | 조광현 | - |
dc.contributor.AlternativeAuthor | 김규한 | - |
dc.contributor.AlternativeAuthor | 은희철 | - |
dc.contributor.AlternativeAuthor | 정진호 | - |
dc.identifier.doi | 10.1111/j.0022-202X.2005.23823.x | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.