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Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients

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Authors
Song, Yeong Wook; Lee, Eun Bong; Whang, Dong Hee; Kang, Su Jin; Takeuchi, Fujio; Park, Myoung Hee
Issue Date
2005-08-23
Publisher
Elsevier/North-Holland
Citation
Hum Immunol. 2005 Jul;66(7):810-7.
Keywords
ATP-Binding Cassette Transporters/*geneticsAdultAgedAntibodies/immunologyDNA Topoisomerases, Type I, Eukaryotic/immunologyFemaleGene FrequencyGenetic Predisposition to Disease/geneticsGenotypeHLA-DR Antigens/geneticsHumansKoreaMaleMiddle AgedPhenotypePolymorphism, Genetic/*geneticsRibonucleoprotein, U1 Small Nuclear/immunologyScleroderma, Diffuse/geneticsScleroderma, Limited/geneticsScleroderma, Systemic/*genetics
Abstract
We sought to determine whether transporter associated with antigen processing (TAP) gene polymorphism is associated with susceptibility to systemic sclerosis (SSc). TAP1 and TAP2 gene polymorphisms were analyzed in 61 Korean patients with SSc and 100 ethnically matched healthy Koreans by polymerase chain reaction-restriction fragment length polymorphism. Human leukocyte antigen (HLA)-DRB1 genotyping data of the patients from our previous study was used for the assessment of independent role of TAP genes to SSc susceptibility. Patients were stratified according to anti-topoisomerase I (anti-topo I) antibody status and clinical subsets of diffuse and limited cutaneous SSc (dcSSc and lcSSc). TAP1 and TAP2 gene polymorphisms were associated with different subsets of SSc: TAP1*A/A genotype with anti-topo I-positive dcSSc (p = 0.01, p corrected = 0.04), TAP2*A1/C genotype with anti-topo I-positive lcSSc (p < 0.05), TAP2*Bky2 and *C alleles with anti-topo I-negative dcSSc (both p < 0.05), and TAP2*B/E genotype with anti-topo I-negative lcSSc (p = 0.004). Although TAP gene associations were generally weak, some associations (TAP2*A1/C, TAP2*C, and TAP2*B/E) with different subsets of SSc were independent of HLA-DR associations, revealing even stronger associations (TAP2*A1/C and TAP2*C) among individuals not possessing the risk HLA-DR alleles. These results suggest the possible role of TAP gene polymorphisms in the genetic susceptibility to SSc.
ISSN
0198-8859 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16112028

http://hdl.handle.net/10371/13087
DOI
https://doi.org/10.1016/j.humimm.2005.03.006
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College of Medicine/School of Medicine (의과대학/대학원)Laboratory Medicine (검사의학전공)Journal Papers (저널논문_검사의학전공)
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